Gene description for Farp1
Gene name FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Gene symbol Farp1
Other names/aliases AW228844
BC030329
Cdep
Species Mus musculus
 Database cross references - Farp1
ExoCarta ExoCarta_223254
Vesiclepedia VP_223254
Entrez Gene 223254
UniProt F8VPU2  
 Farp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Farp1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IGI
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    cytoskeletal protein binding GO:0008092 IEA
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
Biological Process
    enzyme-linked receptor protein signaling pathway GO:0007167 IGI
    synapse assembly GO:0007416 ISO
    synapse assembly GO:0007416 ISS
    Rac protein signal transduction GO:0016601 IGI
    dendrite morphogenesis GO:0048813 ISO
    dendrite morphogenesis GO:0048813 ISS
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 IEA
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 ISO
    postsynaptic actin cytoskeleton organization GO:0098974 IEA
    postsynaptic actin cytoskeleton organization GO:0098974 ISO
    positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904395 IGI
    regulation of presynapse assembly GO:1905606 IEA
    regulation of presynapse assembly GO:1905606 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytoskeleton GO:0005856 IEA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISS
    filopodium GO:0030175 IEA
    dendrite GO:0030425 ISO
    dendrite GO:0030425 ISS
    dendritic spine GO:0043197 IEA
    extrinsic component of postsynaptic membrane GO:0098890 IEA
    extrinsic component of postsynaptic membrane GO:0098890 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Farp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Farp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Farp2  
Co-fractionation Mus musculus
3 Cyfip1 20430
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Fancd2  
Affinity Capture-MS Mus musculus
6 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here