Gene description for FGR
Gene name	FGR proto-oncogene, Src family tyrosine kinase
Gene symbol	FGR
Other names/aliases	SRC2 c-fgr c-src2 p55-Fgr p55c-fgr p58-Fgr p58c-fgr
Species	Homo sapiens
Database cross references - FGR
ExoCarta	ExoCarta_2268
Vesiclepedia	VP_2268
Entrez Gene	2268
HGNC	3697
MIM	164940
UniProt	P09769
FGR identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
Hepatocytes	26054723
Neuroblastoma cells	25944692
Platelets	25332113
Platelets	25332113
Platelets	25332113
Squamous carcinoma cells	20124223

Gene ontology annotations for FGR

Molecular Function     phosphotyrosine residue binding GO:0001784 IPI     phosphotyrosine residue binding GO:0001784 ISS     protein tyrosine kinase activity GO:0004713 EXP     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS     signaling receptor binding GO:0005102 IBA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     protein kinase binding GO:0019901 ISS     immunoglobulin receptor binding GO:0034987 ISS     Fc-gamma receptor I complex binding GO:0034988 IDA     histone H3Y41 kinase activity GO:0035401 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     positive regulation of cytokine production GO:0001819 ISS     immune response-regulating cell surface receptor signaling pathway GO:0002768 TAS     negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 IMP     integrin-mediated signaling pathway GO:0007229 ISS     regulation of cell shape GO:0008360 ISS     response to virus GO:0009615 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     cell differentiation GO:0030154 IBA     bone mineralization GO:0030282 IEA     positive regulation of cell migration GO:0030335 ISS     negative regulation of natural killer cell activation GO:0032815 IEA     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     positive regulation of mast cell degranulation GO:0043306 ISS     regulation of innate immune response GO:0045088 ISS     regulation of protein kinase activity GO:0045859 ISS     protein autophosphorylation GO:0046777 IDA     skeletal system morphogenesis GO:0048705 IEA     regulation of phagocytosis GO:0050764 ISS     defense response to Gram-positive bacterium GO:0050830 ISS     myoblast proliferation GO:0051450 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP Subcellular Localization     extracellular region GO:0005576 TAS     mitochondrial inner membrane GO:0005743 IEA     mitochondrial intermembrane space GO:0005758 IEA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     actin cytoskeleton GO:0015629 ISS     aggresome GO:0016235 IDA     ruffle membrane GO:0032587 ISS     secretory granule lumen GO:0034774 TAS     extracellular exosome GO:0070062 HDA