Gene description for Ahcyl1
Gene name S-adenosylhomocysteine hydrolase-like 1
Gene symbol Ahcyl1
Other names/aliases 1110034F20Rik
AA409031
AA414901
Ahcy-rs3
DCAL
Irbit
Species Mus musculus
 Database cross references - Ahcyl1
ExoCarta ExoCarta_229709
Vesiclepedia VP_229709
Entrez Gene 229709
UniProt Q80SW1  
 Ahcyl1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ahcyl1
Molecular Function
    RNA binding GO:0003723 IEA
    adenosylhomocysteinase activity GO:0004013 IBA
    adenosylhomocysteinase activity GO:0004013 IDA
    protein binding GO:0005515 IPI
    enzyme regulator activity GO:0030234 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    protein export from nucleus GO:0006611 IDA
    one-carbon metabolic process GO:0006730 IEA
    apoptotic process GO:0006915 ISO
    apoptotic process GO:0006915 ISS
    positive regulation of sodium ion transport GO:0010765 IGI
    positive regulation of sodium ion transport GO:0010765 ISO
    regulation of mRNA 3'-end processing GO:0031440 IDA
    regulation of mRNA 3'-end processing GO:0031440 ISO
    regulation of monoatomic ion transmembrane transporter activity GO:0032412 IGI
    regulation of monoatomic ion transmembrane transporter activity GO:0032412 ISO
    S-adenosylmethionine cycle GO:0033353 IBA
    angiotensin-activated signaling pathway GO:0038166 ISO
    angiotensin-activated signaling pathway GO:0038166 ISS
    epithelial fluid transport GO:0042045 IDA
    regulation of monoatomic anion transport GO:0044070 IGI
    response to calcium ion GO:0051592 IEA
    response to calcium ion GO:0051592 ISO
    mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 ISO
    mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISO
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISS
 Experiment description of studies that identified Ahcyl1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ahcyl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Uba6 231380
Co-fractionation Mus musculus
2 Atg5  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ahcyl1 is involved
PathwayEvidenceSource
Cardiac conduction IEA Reactome
Ion homeostasis IEA Reactome
Muscle contraction IEA Reactome





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