Gene description for SMC5
Gene name	structural maintenance of chromosomes 5
Gene symbol	SMC5
Other names/aliases	SMC5L1
Species	Homo sapiens
Database cross references - SMC5
ExoCarta	ExoCarta_23137
Vesiclepedia	VP_23137
Entrez Gene	23137
HGNC	20465
MIM	609386
UniProt	Q8IY18
SMC5 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Endothelial cells	26027894

Gene ontology annotations for SMC5

Molecular Function     DNA secondary structure binding GO:0000217 IDA     single-stranded DNA binding GO:0003697 IBA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP hydrolysis activity GO:0016887 IEA Biological Process     telomere maintenance via recombination GO:0000722 IMP     double-strand break repair via homologous recombination GO:0000724 IBA     double-strand break repair via homologous recombination GO:0000724 IMP     double-strand break repair via homologous recombination GO:0000724 NAS     double-strand break repair via nonhomologous end joining GO:0006303 IMP     DNA damage response GO:0006974 IDA     chromosome segregation GO:0007059 IEA     protein sumoylation GO:0016925 NAS     stem cell population maintenance GO:0019827 IEA     chromosome condensation GO:0030261 IEA     regulation of telomere maintenance GO:0032204 NAS     positive regulation of maintenance of mitotic sister chromatid cohesion GO:0034184 IMP     mitotic cell cycle phase transition GO:0044772 IEA     negative regulation by host of viral genome replication GO:0044828 IDA     cell division GO:0051301 IEA     positive regulation of chromosome segregation GO:0051984 IMP     protein localization to chromosome, centromeric region GO:0071459 IEA     cellular senescence GO:0090398 IMP     chromatin looping GO:0140588 NAS Subcellular Localization     chromosome, centromeric region GO:0000775 IEA     chromosome, telomeric region GO:0000781 IDA     chromosome, telomeric region GO:0000781 NAS     sex chromosome GO:0000803 ISS     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IEA     PML body GO:0016605 IDA     nuclear speck GO:0016607 IDA     cell junction GO:0030054 IDA     Smc5-Smc6 complex GO:0030915 IBA     Smc5-Smc6 complex GO:0030915 IDA     Smc5-Smc6 complex GO:0030915 NAS     interchromatin granule GO:0035061 IDA     site of double-strand break GO:0035861 IDA