Gene description for ZFYVE26
Gene name zinc finger, FYVE domain containing 26
Gene symbol ZFYVE26
Other names/aliases FYVE-CENT
SPG15
Species Homo sapiens
 Database cross references - ZFYVE26
ExoCarta ExoCarta_23503
Vesiclepedia VP_23503
Entrez Gene 23503
HGNC 20761
MIM 612012
UniProt Q68DK2  
 ZFYVE26 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for ZFYVE26
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IDA
    phosphatidylinositol-3-phosphate binding GO:0032266 IBA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    mitotic cytokinesis GO:0000281 IEA
    double-strand break repair via homologous recombination GO:0000724 IMP
    lysosome organization GO:0007040 IDA
    regulation of cytokinesis GO:0032465 IBA
    regulation of cytokinesis GO:0032465 IMP
    autophagosome organization GO:1905037 IDA
Subcellular Localization
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 HDA
    early endosome GO:0005769 IDA
    late endosome GO:0005770 IDA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    midbody GO:0030496 IBA
    midbody GO:0030496 IDA
 Experiment description of studies that identified ZFYVE26 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ZFYVE26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 HNRNPC 3183
Two-hybrid Homo sapiens
3 Pcbp2 18521
Affinity Capture-MS Mus musculus
4 Tyw3  
Affinity Capture-MS Mus musculus
5 LAMTOR1 55004
Proximity Label-MS Homo sapiens
6 Smc3 13006
Affinity Capture-MS Mus musculus
7 TDO2  
Two-hybrid Homo sapiens
8 ALAS1  
Two-hybrid Homo sapiens
9 NPTN 27020
Affinity Capture-MS Homo sapiens
10 AP5S1  
Affinity Capture-MS Homo sapiens
11 KRTAP10-9  
Two-hybrid Homo sapiens
12 MDFI  
Two-hybrid Homo sapiens
13 LAMP2 3920
Proximity Label-MS Homo sapiens
14 PNMA1 9240
Two-hybrid Homo sapiens
15 KRTAP10-3  
Two-hybrid Homo sapiens
16 Csk 12988
Affinity Capture-MS Mus musculus
17 GOLGA2 2801
Two-hybrid Homo sapiens
18 PNMA5 114824
Two-hybrid Homo sapiens
19 KRT15 3866
Two-hybrid Homo sapiens
20 FIS1 51024
Affinity Capture-MS Homo sapiens
21 TADA2A  
Two-hybrid Homo sapiens
22 SPAG5 10615
Two-hybrid Homo sapiens
23 RAB9A 9367
Proximity Label-MS Homo sapiens
24 KRT40  
Two-hybrid Homo sapiens
25 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 USHBP1  
Two-hybrid Homo sapiens
27 TFIP11  
Two-hybrid Homo sapiens
28 HYPM  
Affinity Capture-MS Homo sapiens
29 CEP44  
Two-hybrid Homo sapiens
30 KIAA0226  
Affinity Capture-MS Homo sapiens
31 TRAF1 7185
Two-hybrid Homo sapiens
32 SSX2IP  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZFYVE26 is involved
No pathways found





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