Gene description for Rbm10
Gene name RNA binding motif protein 10
Gene symbol Rbm10
Other names/aliases E430039K10Rik
Species Mus musculus
 Database cross references - Rbm10
ExoCarta ExoCarta_236732
Vesiclepedia VP_236732
Entrez Gene 236732
UniProt Q99KG3  
 Rbm10 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rbm10
Molecular Function
    RNA binding GO:0003723 IBA
    single-stranded RNA binding GO:0003727 ISO
    miRNA binding GO:0035198 ISO
    miRNA binding GO:0035198 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    mRNA splicing, via spliceosome GO:0000398 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IMP
    mRNA stabilization GO:0048255 ISO
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 ISO
    3'-UTR-mediated mRNA stabilization GO:0070935 IDA
    positive regulation of execution phase of apoptosis GO:1900119 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IGI
    vascular associated smooth muscle cell apoptotic process GO:1905288 IDA
    regulation of vascular associated smooth muscle cell apoptotic process GO:1905459 IGI
    positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 IDA
    vascular associated smooth muscle cell proliferation GO:1990874 IGI
    negative regulation of ribosomal large subunit export from nucleus GO:2000204 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Rbm10 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rbm10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Proximity Label-MS Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Lmna 16905
Affinity Capture-MS Mus musculus
4 Atg16l1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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