Gene description for Dlg2
Gene name discs, large homolog 2 (Drosophila)
Gene symbol Dlg2
Other names/aliases A330103J02Rik
B230218P12Rik
B330007M19Rik
Dlgh2
Gm1197
PSD93
Species Mus musculus
 Database cross references - Dlg2
ExoCarta ExoCarta_23859
Vesiclepedia VP_23859
Entrez Gene 23859
UniProt Q91XM9  
 Dlg2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dlg2
Molecular Function
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 ISO
    protein kinase binding GO:0019901 IBA
    protein phosphatase binding GO:0019903 ISO
    PDZ domain binding GO:0030165 ISO
    ionotropic glutamate receptor binding GO:0035255 IBA
    protein-containing complex binding GO:0044877 ISO
    structural constituent of postsynaptic density GO:0098919 IDA
    structural constituent of postsynaptic density GO:0098919 IEP
    structural constituent of postsynaptic density GO:0098919 IMP
Biological Process
    chemical synaptic transmission GO:0007268 IBA
    chemical synaptic transmission GO:0007268 IMP
    nervous system development GO:0007399 IBA
    sensory perception of pain GO:0019233 IMP
    protein localization to synapse GO:0035418 IBA
    cellular response to potassium ion GO:0035865 IDA
    receptor clustering GO:0043113 IBA
    receptor clustering GO:0043113 ISO
    neuronal ion channel clustering GO:0045161 ISO
    clustering of voltage-gated potassium channels GO:0045163 IDA
    clustering of voltage-gated potassium channels GO:0045163 IMP
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IBA
    receptor localization to synapse GO:0097120 IBA
    cell-cell adhesion GO:0098609 IBA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IBA
    maintenance of postsynaptic density structure GO:0099562 IEA
    anterograde axonal protein transport GO:0099641 IGI
    retrograde axonal protein transport GO:0099642 IGI
    neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IDA
    neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IEP
    neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IMP
Subcellular Localization
    voltage-gated potassium channel complex GO:0008076 ISO
    voltage-gated potassium channel complex GO:0008076 ISS
    postsynaptic density GO:0014069 IDA
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IBA
    cell junction GO:0030054 IDA
    dendrite GO:0030425 ISO
    synaptic vesicle membrane GO:0030672 IDA
    neuromuscular junction GO:0031594 IBA
    neuromuscular junction GO:0031594 IEA
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 ISO
    axon initial segment GO:0043194 IDA
    axon initial segment GO:0043194 IMP
    perikaryon GO:0043204 IEA
    juxtaparanode region of axon GO:0044224 IDA
    juxtaparanode region of axon GO:0044224 ISO
    postsynaptic membrane GO:0045211 IDA
    postsynaptic density membrane GO:0098839 IBA
    postsynaptic density membrane GO:0098839 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified Dlg2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dlg2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dlg3  
Affinity Capture-MS Mus musculus
2 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Grin2b  
Affinity Capture-Western Mus musculus
5 Cnksr2  
Affinity Capture-MS Mus musculus
6 Cyfip1 20430
Affinity Capture-MS Mus musculus
7 Kctd13  
Affinity Capture-MS Mus musculus
8 Mycbp2 105689
Affinity Capture-MS Mus musculus
9 Agap2  
Affinity Capture-MS Mus musculus
10 Kalrn  
Affinity Capture-MS Mus musculus
11 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
12 Tnik  
Affinity Capture-MS Mus musculus
13 Fmr1  
Affinity Capture-MS Mus musculus
14 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
15 Grin1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
16 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
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