Gene description for Sord
Gene name sorbitol dehydrogenase
Gene symbol Sord
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Sord
ExoCarta ExoCarta_24788
Vesiclepedia VP_24788
Entrez Gene 24788
UniProt P27867  
 Sord identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sord
Molecular Function
    L-iditol 2-dehydrogenase (NAD+) activity GO:0003939 IBA
    L-iditol 2-dehydrogenase (NAD+) activity GO:0003939 IEA
    L-iditol 2-dehydrogenase (NAD+) activity GO:0003939 ISO
    zinc ion binding GO:0008270 IDA
    zinc ion binding GO:0008270 IEA
    zinc ion binding GO:0008270 ISO
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    D-xylulose reductase activity GO:0046526 IEA
    D-xylulose reductase activity GO:0046526 ISO
    D-sorbitol dehydrogenase (acceptor) activity GO:0047833 IEA
    D-sorbitol dehydrogenase (acceptor) activity GO:0047833 ISO
    NAD binding GO:0051287 IEA
    NAD binding GO:0051287 ISO
Biological Process
    sorbitol metabolic process GO:0006060 ISO
    sorbitol catabolic process GO:0006062 IBA
    sorbitol catabolic process GO:0006062 IEA
    sorbitol catabolic process GO:0006062 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    response to hormone GO:0009725 IDA
    D-glucuronate catabolic process to D-xylulose 5-phosphate GO:0019640 IEA
    D-glucuronate catabolic process to D-xylulose 5-phosphate GO:0019640 ISO
    flagellated sperm motility GO:0030317 IEA
    flagellated sperm motility GO:0030317 ISO
    flagellated sperm motility GO:0030317 ISS
    response to nutrient levels GO:0031667 IEP
    fructose biosynthetic process GO:0046370 IEA
    fructose biosynthetic process GO:0046370 ISO
    response to cadmium ion GO:0046686 IDA
    response to copper ion GO:0046688 IDA
    xylitol catabolic process GO:0051160 IEA
    xylitol catabolic process GO:0051160 ISO
    xylitol metabolic process GO:0051164 ISO
Subcellular Localization
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    motile cilium GO:0031514 IEA
    motile cilium GO:0031514 ISO
    motile cilium GO:0031514 ISS
    mitochondrial membrane GO:0031966 IEA
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Sord in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sord
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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