FAM133B 
                                                                        
                                                                            
                                                                                
                                                                         
                                                                     
                                                            
                                                            
                                                         
                                                        
                                                        
                                                            
                                                                FAM133B  in sEVs
                                                                                
                                                                                    
                                                                                        
                                                                                            1 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        834 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            35333565
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        LAMP2A regulates the loading of proteins into exosomes 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Sci Adv 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2022 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Retinal pigment epithelial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        ARPE-19 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            2 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        835 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            35333565
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        LAMP2A regulates the loading of proteins into exosomes 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Sci Adv 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2022 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Retinal pigment epithelial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        ARPE-19 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                        
                                                                            FAM133B 
                                                                                
                                                                                    
                                                                                        
                                                                                              
                                                                                            Protein Interactor 
                                                                                            ExoCarta ID 
                                                                                            Identification method 
                                                                                            PubMed 
                                                                                            Species 
                                                                                         
                                                                                                                                                                                    
                                                                                                
                                                                                                    1 
                                                                                                                                                                                                                GNL2 
                                                                                                            29889 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    2 
                                                                                                                                                                                                                ATG16L1 
                                                                                                            55054 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    3 
                                                                                                                                                                                                            ATR 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    4 
                                                                                                                                                                                                                UBE2H 
                                                                                                            7328 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    5 
                                                                                                                                                                                                            MYCN 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    6 
                                                                                                                                                                                                                S100P 
                                                                                                            6286 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    7 
                                                                                                                                                                                                            PPP4R2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    8 
                                                                                                                                                                                                                TP53 
                                                                                                            7157 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    9 
                                                                                                                                                                                                            C6orf201 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    10 
                                                                                                                                                                                                                DDX58 
                                                                                                            23586 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-RNA 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    11 
                                                                                                                                                                                                                APP 
                                                                                                            351 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Reconstituted Complex 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    12 
                                                                                                                                                                                                            C20orf197 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    13 
                                                                                                                                                                                                                CDK2 
                                                                                                            1017 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    14 
                                                                                                                                                                                                            MYC 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    15 
                                                                                                                                                                                                                YAP1 
                                                                                                            10413 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    16 
                                                                                                                                                                                                                TSNAX 
                                                                                                            7257 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    17 
                                                                                                                                                                                                            RAD18 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    18 
                                                                                                                                                                                                                HECTD1 
                                                                                                            25831 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    19 
                                                                                                                                                                                                                LMNA 
                                                                                                            4000 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Cross-Linking-MS (XL-MS) 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    20 
                                                                                                                                                                                                            HECW2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    21 
                                                                                                                                                                                                                PEA15 
                                                                                                            8682 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    22 
                                                                                                                                                                                                                FAM133A 
                                                                                                            286499 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                                                                                                                
                                                                                                    
                                                                                                        View the network 
                                                                                                     
                                                                                                    
                                                                                                        
                                                                                                                    
                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                            image/svg+xml 
                                                                                                                             
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                         
                                                                                                     
                                                                                                 
                                                                                                                                                                            
                                                                                 
                                                                             
                                                            
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                        FAM133B  is involved
                                                                            
                                                                                                                                                                            No pathways found