Gene description for Strn
Gene name striatin, calmodulin binding protein
Gene symbol Strn
Other names/aliases AU022939
D130055P19
Species Mus musculus
 Database cross references - Strn
ExoCarta ExoCarta_268980
Vesiclepedia VP_268980
Entrez Gene 268980
UniProt O55106  
 Strn identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Strn
Molecular Function
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 IEA
    calmodulin binding GO:0005516 ISO
    protein domain specific binding GO:0019904 ISO
    nuclear estrogen receptor binding GO:0030331 IEA
    nuclear estrogen receptor binding GO:0030331 ISO
    protein-containing complex binding GO:0044877 IBA
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    protein phosphatase 2A binding GO:0051721 IBA
    protein phosphatase 2A binding GO:0051721 IEA
    protein phosphatase 2A binding GO:0051721 ISO
    armadillo repeat domain binding GO:0070016 IEA
    armadillo repeat domain binding GO:0070016 ISO
Biological Process
    locomotory behavior GO:0007626 ISO
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    regulation of signal transduction GO:0009966 IBA
    Wnt signaling pathway GO:0016055 IBA
    Wnt signaling pathway GO:0016055 IEA
    Wnt signaling pathway GO:0016055 ISO
    dendrite development GO:0016358 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    bicellular tight junction GO:0005923 IEA
    bicellular tight junction GO:0005923 ISO
    membrane GO:0016020 IEA
    dendrite GO:0030425 IBA
    protein-containing complex GO:0032991 ISO
    neuronal cell body GO:0043025 ISO
    dendritic spine GO:0043197 IEA
    dendritic spine GO:0043197 ISO
    postsynaptic membrane GO:0045211 ISO
    FAR/SIN/STRIPAK complex GO:0090443 IBA
    FAR/SIN/STRIPAK complex GO:0090443 IEA
    FAR/SIN/STRIPAK complex GO:0090443 ISO
 Experiment description of studies that identified Strn in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Strn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fxr1 14359
Affinity Capture-MS Mus musculus
2 Syngap1  
Affinity Capture-MS Mus musculus
3 Stk4 58231
Co-fractionation Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Pde4dip  
Affinity Capture-MS Mus musculus
6 Rabgef1  
Co-fractionation Mus musculus
7 Agap2  
Affinity Capture-MS Mus musculus
8 Atg16l1  
Affinity Capture-MS Mus musculus
9 Ralgapa1  
Co-fractionation Mus musculus
10 Eif4ebp1  
Co-fractionation Mus musculus
11 Fancd2  
Affinity Capture-MS Mus musculus
12 Ywhaz 22631
Affinity Capture-MS Mus musculus
13 Tnik  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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