Gene description for GNA15
Gene name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Gene symbol GNA15
Other names/aliases GNA16
Species Homo sapiens
 Database cross references - GNA15
ExoCarta ExoCarta_2769
Vesiclepedia VP_2769
Entrez Gene 2769
HGNC 4383
MIM 139314
UniProt P30679  
 GNA15 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for GNA15
Molecular Function
    G protein-coupled receptor binding GO:0001664 IDA
    GTPase activity GO:0003924 TAS
    GTP binding GO:0005525 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207 TAS
    calcium-mediated signaling GO:0019722 IPI
Subcellular Localization
    heterotrimeric G-protein complex GO:0005834 NAS
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 IEA
 Experiment description of studies that identified GNA15 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNA15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 ADRBK1 156
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 APPBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RGS2  
Reconstituted Complex Homo sapiens
5 TTC1 7265
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 MNAT1  
Affinity Capture-MS Homo sapiens
7 C2orf44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FECH 2235
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GNA15 is involved
PathwayEvidenceSource
Acetylcholine regulates insulin secretion TAS Reactome
Acetylcholine regulates insulin secretion IEA Reactome
ADP signalling through P2Y purinoceptor 1 TAS Reactome
ADP signalling through P2Y purinoceptor 1 IEA Reactome
Chaperonin-mediated protein folding TAS Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding TAS Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TAS Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion IEA Reactome
Free fatty acids regulate insulin secretion TAS Reactome
Free fatty acids regulate insulin secretion IEA Reactome
G alpha (i) signalling events TAS Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events IEA Reactome
G-protein activation TAS Reactome
G-protein mediated events TAS Reactome
G-protein mediated events IEA Reactome
GPCR downstream signalling TAS Reactome
GPCR downstream signalling IEA Reactome
Hemostasis TAS Reactome
Hemostasis IEA Reactome
Integration of energy metabolism TAS Reactome
Integration of energy metabolism IEA Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of proteins TAS Reactome
Opioid Signalling TAS Reactome
Opioid Signalling IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet activation, signaling and aggregation IEA Reactome
PLC beta mediated events TAS Reactome
PLC beta mediated events IEA Reactome
Protein folding TAS Reactome
Regulation of insulin secretion TAS Reactome
Regulation of insulin secretion IEA Reactome
Signal amplification TAS Reactome
Signal amplification IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by GPCR TAS Reactome
Signaling by GPCR IEA Reactome
Thrombin signalling through proteinase activated receptors (PARs) TAS Reactome
Thromboxane signalling through TP receptor TAS Reactome





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