Gene description for CCDC88B
Gene name coiled-coil domain containing 88B
Gene symbol CCDC88B
Other names/aliases BRLZ
CCDC88
HKRP3
gipie
Species Homo sapiens
 Database cross references - CCDC88B
ExoCarta ExoCarta_283234
Vesiclepedia VP_283234
Entrez Gene 283234
HGNC 26757
MIM 611205
UniProt A6NC98  
 CCDC88B identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CCDC88B
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    positive regulation of cytokine production GO:0001819 ISS
    cytoskeleton-dependent intracellular transport GO:0030705 IBA
    cytoplasmic microtubule organization GO:0031122 IBA
    positive regulation of T cell proliferation GO:0042102 ISS
    defense response to protozoan GO:0042832 IEA
    positive regulation of T cell activation GO:0050870 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified CCDC88B in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CCDC88B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BEX2  
Two-hybrid Homo sapiens
2 CDC73  
Affinity Capture-MS Homo sapiens
3 LMNB1 4001
Two-hybrid Homo sapiens
4 HOXB5  
Two-hybrid Homo sapiens
5 PIN1 5300
Two-hybrid Homo sapiens
6 TSHZ2  
Two-hybrid Homo sapiens
7 LMNB2 84823
Two-hybrid Homo sapiens
8 TXLNB  
Two-hybrid Homo sapiens
9 CCHCR1  
Two-hybrid Homo sapiens
10 TSGA10IP  
Two-hybrid Homo sapiens
11 CDK18 5129
Two-hybrid Homo sapiens
12 FAM161B  
Two-hybrid Homo sapiens
13 CWF19L2  
Two-hybrid Homo sapiens
14 HCK 3055
Two-hybrid Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
16 KRT27 342574
Affinity Capture-MS Homo sapiens
17 PLEKHA5 54477
Two-hybrid Homo sapiens
18 GEM  
Two-hybrid Homo sapiens
19 CARD9 64170
Two-hybrid Homo sapiens
20 JAKMIP2  
Two-hybrid Homo sapiens
21 DTNB 1838
Two-hybrid Homo sapiens
22 FAM161A  
Two-hybrid Homo sapiens
23 RINT1 60561
Two-hybrid Homo sapiens
24 NME7 29922
Two-hybrid Homo sapiens
25 C1orf109  
Two-hybrid Homo sapiens
26 KANK2 25959
Two-hybrid Homo sapiens
27 PPP1R18 170954
Two-hybrid Homo sapiens
28 SH2D4A 63898
Two-hybrid Homo sapiens
29 LMO1  
Two-hybrid Homo sapiens
30 ZC2HC1C  
Two-hybrid Homo sapiens
31 SH3KBP1 30011
Two-hybrid Homo sapiens
32 TSGA10  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CCDC88B is involved
No pathways found





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