Gene description for ANGPT1
Gene name	angiopoietin 1
Gene symbol	ANGPT1
Other names/aliases	AGP1 AGPT ANG1
Species	Homo sapiens
Database cross references - ANGPT1
ExoCarta	ExoCarta_284
Vesiclepedia	VP_284
Entrez Gene	284
HGNC	484
MIM	601667
UniProt	Q15389
ANGPT1 identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Saliva	19199708

Gene ontology annotations for ANGPT1

Molecular Function     protein binding GO:0005515 IPI     receptor tyrosine kinase binding GO:0030971 IBA     receptor tyrosine kinase binding GO:0030971 IPI     identical protein binding GO:0042802 IPI     receptor ligand activity GO:0048018 IDA Biological Process     angiogenesis GO:0001525 IBA     in utero embryonic development GO:0001701 IEA     positive regulation of protein phosphorylation GO:0001934 IMP     regulation of endothelial cell proliferation GO:0001936 IDA     sprouting angiogenesis GO:0002040 IDA     positive regulation of receptor internalization GO:0002092 IDA     negative regulation of cytokine production involved in immune response GO:0002719 IEA     negative regulation of cell adhesion GO:0007162 IDA     activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 IDA     blood coagulation GO:0007596 IEA     positive regulation of endothelial cell migration GO:0010595 IDA     positive regulation of gene expression GO:0010628 IMP     regulation of skeletal muscle satellite cell proliferation GO:0014842 IDA     hemopoiesis GO:0030097 IEA     heparin biosynthetic process GO:0030210 IDA     positive regulation of protein ubiquitination GO:0031398 IDA     cell-substrate adhesion GO:0031589 IEA     regulation of tumor necrosis factor production GO:0032680 IEA     protein localization to cell surface GO:0034394 IDA     negative regulation of protein import into nucleus GO:0042308 IEA     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of vascular permeability GO:0043116 IDA     regulation of canonical NF-kappaB signal transduction GO:0043122 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 IDA     positive regulation of cell adhesion GO:0045785 IEA     Tie signaling pathway GO:0048014 IBA     Tie signaling pathway GO:0048014 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     positive regulation of coagulation GO:0050820 IDA     positive chemotaxis GO:0050918 IDA     neuron apoptotic process GO:0051402 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     glomerulus vasculature development GO:0072012 ISS     positive regulation of blood-brain barrier permeability GO:1905605 IMP     negative regulation of endothelial cell apoptotic process GO:2000352 IDA     regulation of macrophage migration inhibitory factor signaling pathway GO:2000446 IEA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     plasma membrane GO:0005886 IDA     microvillus GO:0005902 IDA     membrane raft GO:0045121 IDA     collagen-containing extracellular matrix GO:0062023 IBA     extracellular exosome GO:0070062 HDA