Gene description for SLC9C1
Gene name solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Gene symbol SLC9C1
Other names/aliases NHE
SLC9A10
sperm-NHE
Species Homo sapiens
 Database cross references - SLC9C1
ExoCarta ExoCarta_285335
Vesiclepedia VP_285335
Entrez Gene 285335
HGNC 31401
MIM 612738
UniProt Q4G0N8  
 SLC9C1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SLC9C1
Molecular Function
    monoatomic ion channel activity GO:0005216 IEA
    sodium:proton antiporter activity GO:0015385 IBA
    potassium:proton antiporter activity GO:0015386 IBA
Biological Process
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
    flagellated sperm motility GO:0030317 IEA
    regulation of intracellular pH GO:0051453 IBA
    potassium ion transmembrane transport GO:0071805 IBA
    sodium ion import across plasma membrane GO:0098719 IBA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    motile cilium GO:0031514 IEA
 Experiment description of studies that identified SLC9C1 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SLC9C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPAG5 10615
Affinity Capture-MS Homo sapiens
2 OBSL1 23363
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC9C1 is involved
PathwayEvidenceSource
Ion channel transport IEA Reactome
Stimuli-sensing channels IEA Reactome
Transport of small molecules IEA Reactome





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