Gene description for LRP12
Gene name low density lipoprotein receptor-related protein 12
Gene symbol LRP12
Other names/aliases ST7
Species Homo sapiens
 Database cross references - LRP12
ExoCarta ExoCarta_29967
Vesiclepedia VP_29967
Entrez Gene 29967
HGNC 31708
UniProt Q9Y561  
 LRP12 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRP12
Molecular Function
    low-density lipoprotein particle receptor activity GO:0005041 NAS
    protein binding GO:0005515 IPI
Biological Process
    neuron migration GO:0001764 IDA
    endocytosis GO:0006897 NAS
    signal transduction GO:0007165 NAS
    neuron projection development GO:0031175 IDA
    regulation of growth GO:0040008 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    clathrin-coated pit GO:0005905 IEA
    membrane GO:0016020 NAS
 Experiment description of studies that identified LRP12 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRP12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRP3  
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Affinity Capture-MS Homo sapiens
3 CHRNE  
Affinity Capture-MS Homo sapiens
4 HFE  
Affinity Capture-MS Homo sapiens
5 RXFP1  
Affinity Capture-MS Homo sapiens
6 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAM189B  
Affinity Capture-MS Homo sapiens
8 KLRC2  
Affinity Capture-MS Homo sapiens
9 KLRC3  
Affinity Capture-MS Homo sapiens
10 OR10H1  
Affinity Capture-MS Homo sapiens
11 GLRA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TMEM59 9528
Affinity Capture-MS Homo sapiens
14 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 WWP1 11059
Affinity Capture-MS Homo sapiens
16 PCDHB1  
Affinity Capture-MS Homo sapiens
17 ARRDC4  
Affinity Capture-MS Homo sapiens
18 NRSN1  
Affinity Capture-MS Homo sapiens
19 LRRC55  
Affinity Capture-MS Homo sapiens
20 ADAM33 80332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CLEC12B  
Affinity Capture-MS Homo sapiens
24 FAM168A  
Affinity Capture-MS Homo sapiens
25 NUP43 348995
Proximity Label-MS Homo sapiens
26 KLRAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 KIR3DL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MPL 4352
Affinity Capture-MS Homo sapiens
29 BRICD5  
Affinity Capture-MS Homo sapiens
30 IFNAR1  
Affinity Capture-MS Homo sapiens
31 FAM69A 388650
Affinity Capture-MS Homo sapiens
32 CTLA4  
Affinity Capture-MS Homo sapiens
33 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 MARCH4  
Affinity Capture-MS Homo sapiens
36 KIR2DL4  
Affinity Capture-MS Homo sapiens
37 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 IL17RC 84818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KLRC1  
Affinity Capture-MS Homo sapiens
40 CHRNB1  
Affinity Capture-MS Homo sapiens
41 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 C3orf52  
Affinity Capture-MS Homo sapiens
45 TMPRSS13  
Affinity Capture-MS Homo sapiens
46 TAS1R2  
Affinity Capture-MS Homo sapiens
47 IGFL3  
Affinity Capture-MS Homo sapiens
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