Gene description for HAL
Gene name histidine ammonia-lyase
Gene symbol HAL
Other names/aliases HIS
HSTD
Species Homo sapiens
 Database cross references - HAL
ExoCarta ExoCarta_3034
Vesiclepedia VP_3034
Entrez Gene 3034
HGNC 4806
MIM 609457
UniProt P42357  
 HAL identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for HAL
Molecular Function
    histidine ammonia-lyase activity GO:0004397 EXP
    histidine ammonia-lyase activity GO:0004397 IBA
Biological Process
    L-histidine catabolic process GO:0006548 IBA
    L-histidine catabolic process GO:0006548 TAS
    L-histidine catabolic process to glutamate and formamide GO:0019556 IEA
    L-histidine catabolic process to glutamate and formate GO:0019557 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified HAL in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HAL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLEKHA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
3 BPHL 670
Affinity Capture-MS Homo sapiens
4 C6orf62 81688
Affinity Capture-MS Homo sapiens
5 RPS19BP1  
Affinity Capture-MS Homo sapiens
6 LHX2  
Affinity Capture-MS Homo sapiens
7 TLR7  
Affinity Capture-MS Homo sapiens
8 UBE3A 7337
Affinity Capture-MS Homo sapiens
9 EBF2  
Affinity Capture-MS Homo sapiens
10 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 C10orf120  
Affinity Capture-MS Homo sapiens
12 SOX2  
Affinity Capture-MS Homo sapiens
13 PI4KA 5297
Affinity Capture-MS Homo sapiens
14 SLC39A3  
Affinity Capture-MS Homo sapiens
15 DPPA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MCM2 4171
Affinity Capture-MS Homo sapiens
17 WNT8B 7479
Affinity Capture-MS Homo sapiens
18 VEGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 E2F6 1876
Affinity Capture-MS Homo sapiens
20 POU5F1  
Affinity Capture-MS Homo sapiens
21 OR13C3  
Affinity Capture-MS Homo sapiens
22 PHF11 51131
Affinity Capture-MS Homo sapiens
23 MOGAT3  
Affinity Capture-MS Homo sapiens
24 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LHX4  
Affinity Capture-MS Homo sapiens
26 IFNA4  
Affinity Capture-MS Homo sapiens
27 MLLT1 4298
Affinity Capture-MS Homo sapiens
28 AHDC1  
Affinity Capture-MS Homo sapiens
29 C18orf21  
Affinity Capture-MS Homo sapiens
30 NDUFS5 4725
Affinity Capture-MS Homo sapiens
31 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SLCO6A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TLX3  
Affinity Capture-MS Homo sapiens
35 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
36 SFR1 119392
Affinity Capture-MS Homo sapiens
37 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
38 RNF115  
Affinity Capture-MS Homo sapiens
39 STX17 55014
Affinity Capture-MS Homo sapiens
40 UBAC2 337867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 FANCG 2189
Affinity Capture-MS Homo sapiens
42 ITLN2  
Affinity Capture-MS Homo sapiens
43 SARAF  
Affinity Capture-MS Homo sapiens
44 PIGT 51604
Affinity Capture-MS Homo sapiens
45 LHX3  
Affinity Capture-MS Homo sapiens
46 SPRR2D  
Affinity Capture-MS Homo sapiens
47 SSUH2  
Affinity Capture-MS Homo sapiens
48 ALDH3A1 218
Affinity Capture-MS Homo sapiens
49 FGFRL1 53834
Affinity Capture-MS Homo sapiens
50 ZRSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 HCN1  
Affinity Capture-MS Homo sapiens
52 APTX  
Affinity Capture-MS Homo sapiens
53 FCAR  
Affinity Capture-MS Homo sapiens
54 CCDC27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CYLD  
Affinity Capture-MS Homo sapiens
56 TLX2  
Affinity Capture-MS Homo sapiens
57 DTL  
Affinity Capture-MS Homo sapiens
58 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
59 VWA3B 200403
Affinity Capture-MS Homo sapiens
60 AGPAT1 10554
Affinity Capture-MS Homo sapiens
61 RAB9B 51209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 ELK3  
Affinity Capture-MS Homo sapiens
63 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 GPR18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DOCK10 55619
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PAX8  
Affinity Capture-MS Homo sapiens
67 CD274 29126
Affinity Capture-MS Homo sapiens
68 UCP2  
Affinity Capture-MS Homo sapiens
69 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
71 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 THRA  
Affinity Capture-MS Homo sapiens
75 HES4  
Affinity Capture-MS Homo sapiens
76 TSPAN8 7103
Affinity Capture-MS Homo sapiens
77 PI4KAP1  
Affinity Capture-MS Homo sapiens
78 ETV3  
Affinity Capture-MS Homo sapiens
79 UBE2J2 118424
Affinity Capture-MS Homo sapiens
80 PLCZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 VDAC1 7416
Affinity Capture-MS Homo sapiens
82 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 PSMB1 5689
Affinity Capture-MS Homo sapiens
84 PFDN5 5204
Affinity Capture-MS Homo sapiens
85 PRSS16 10279
Affinity Capture-MS Homo sapiens
86 FGL1  
Affinity Capture-MS Homo sapiens
87 TXNDC16 57544
Affinity Capture-MS Homo sapiens
88 SLC25A6 293
Affinity Capture-MS Homo sapiens
89 TP53 7157
Affinity Capture-MS Homo sapiens
90 SCGB1D1  
Affinity Capture-MS Homo sapiens
91 COQ5  
Affinity Capture-MS Homo sapiens
92 POLR2L 5441
Affinity Capture-MS Homo sapiens
93 ZNF154  
Affinity Capture-MS Homo sapiens
94 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 C1orf35  
Affinity Capture-MS Homo sapiens
96 MBNL1 4154
Affinity Capture-MS Homo sapiens
97 HEXIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 THAP4 51078
Affinity Capture-MS Homo sapiens
99 TEFM  
Affinity Capture-MS Homo sapiens
100 TRIP4 9325
Affinity Capture-MS Homo sapiens
101 UBALD2  
Affinity Capture-MS Homo sapiens
102 GOT1 2805
Affinity Capture-MS Homo sapiens
103 RNF111 54778
Affinity Capture-MS Homo sapiens
104 KCTD16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 STK11 6794
Affinity Capture-MS Homo sapiens
106 GLYR1 84656
Affinity Capture-MS Homo sapiens
107 XRCC6 2547
Proximity Label-MS Homo sapiens
108 PRKX 5613
Affinity Capture-MS Homo sapiens
109 OR2A4 79541
Affinity Capture-MS Homo sapiens
110 SLC39A11  
Affinity Capture-MS Homo sapiens
111 CCR1  
Affinity Capture-MS Homo sapiens
112 SP7  
Affinity Capture-MS Homo sapiens
113 GUCY1A3  
Affinity Capture-MS Homo sapiens
114 P2RX6  
Affinity Capture-MS Homo sapiens
115 GALNT9  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HAL is involved
PathwayEvidenceSource
Histidine catabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome





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