Gene description for NRG1
Gene name neuregulin 1
Gene symbol NRG1
Other names/aliases ARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
Species Homo sapiens
 Database cross references - NRG1
ExoCarta ExoCarta_3084
Vesiclepedia VP_3084
Entrez Gene 3084
HGNC 7997
MIM 142445
UniProt Q02297  
 NRG1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NRG1
Molecular Function
    transcription coregulator activity GO:0003712 IDA
    signaling receptor binding GO:0005102 IPI
    cytokine activity GO:0005125 TAS
    integrin binding GO:0005178 IDA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IDA
    growth factor activity GO:0008083 NAS
    protein tyrosine kinase activator activity GO:0030296 IBA
    protein tyrosine kinase activator activity GO:0030296 IDA
    transmembrane receptor protein tyrosine kinase activator activity GO:0030297 IC
    transmembrane receptor protein tyrosine kinase activator activity GO:0030297 NAS
    receptor tyrosine kinase binding GO:0030971 NAS
    ErbB-3 class receptor binding GO:0043125 IDA
    ErbB-3 class receptor binding GO:0043125 IPI
    chemorepellent activity GO:0045499 IBA
    receptor ligand activity GO:0048018 IDA
Biological Process
    ventricular trabecula myocardium morphogenesis GO:0003222 IDA
    cell communication GO:0007154 TAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 IDA
    nervous system development GO:0007399 TAS
    brain development GO:0007420 IBA
    peripheral nervous system development GO:0007422 IBA
    cell population proliferation GO:0008283 IDA
    positive regulation of cell population proliferation GO:0008284 IMP
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 IDA
    neural crest cell development GO:0014032 TAS
    cell differentiation GO:0030154 IBA
    positive regulation of cell growth GO:0030307 IDA
    mammary gland development GO:0030879 TAS
    positive regulation of protein-containing complex assembly GO:0031334 IDA
    positive regulation of protein-containing complex assembly GO:0031334 TAS
    activation of protein kinase B activity GO:0032148 IMP
    intracellular signal transduction GO:0035556 IBA
    ERBB signaling pathway GO:0038127 IDA
    ERBB signaling pathway GO:0038127 IMP
    ERBB3 signaling pathway GO:0038129 IDA
    ERBB4 signaling pathway GO:0038130 IBA
    ERBB4 signaling pathway GO:0038130 IDA
    ERBB2-ERBB3 signaling pathway GO:0038133 IBA
    ERBB2-ERBB3 signaling pathway GO:0038133 IDA
    ERBB2-ERBB4 signaling pathway GO:0038135 IDA
    ERBB4-ERBB4 signaling pathway GO:0038138 IDA
    wound healing GO:0042060 IDA
    wound healing GO:0042060 TAS
    positive regulation of cell adhesion GO:0045785 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative chemotaxis GO:0050919 IEA
    negative regulation of secretion GO:0051048 IDA
    positive regulation of striated muscle cell differentiation GO:0051155 ISS
    sequestering of metal ion GO:0051238 EXP
    cardiac muscle cell differentiation GO:0055007 ISS
    ventricular cardiac muscle cell differentiation GO:0055012 IDA
    positive regulation of cardiac muscle cell proliferation GO:0060045 IDA
    cardiac muscle cell myoblast differentiation GO:0060379 IDA
    endocardial cell differentiation GO:0060956 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IDA
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IMP
    positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 IDA
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 NAS
    apical plasma membrane GO:0016324 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified NRG1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM164  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HMOX1 3162
Affinity Capture-MS Homo sapiens
3 MTCH1 23787
Affinity Capture-MS Homo sapiens
4 LGR4 55366
Affinity Capture-MS Homo sapiens
5 CNTNAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NETO2  
Affinity Capture-MS Homo sapiens
7 SCNN1A  
Affinity Capture-MS Homo sapiens
8 CD72  
Two-hybrid Homo sapiens
9 KIAA2013 90231
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LPHN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMEM205 374882
Affinity Capture-MS Homo sapiens
12 ASGR2  
Two-hybrid Homo sapiens
13 OPA3 80207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 POMGNT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DEGS1  
Affinity Capture-MS Homo sapiens
16 CHST10  
Affinity Capture-MS Homo sapiens
17 ABCA3 21
Affinity Capture-MS Homo sapiens
18 TM2D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TMEM181 57583
Affinity Capture-MS Homo sapiens
21 B4GALT7 11285
Affinity Capture-MS Homo sapiens
22 MGAT1 4245
Affinity Capture-MS Homo sapiens
23 B3GAT3 26229
Affinity Capture-MS Homo sapiens
24 HS6ST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TMTC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 LIMK1 3984
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 POMT1 10585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ERBB2 2064
Reconstituted Complex Homo sapiens
29 UQCRQ 27089
Affinity Capture-MS Homo sapiens
30 TMEM63B 55362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TMEM54  
Two-hybrid Homo sapiens
33 Erbb4 13869
Co-localization Mus musculus
34 ERBB3 2065
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
35 JAGN1 84522
Two-hybrid Homo sapiens
36 SFXN3 81855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 UGT8  
Affinity Capture-MS Homo sapiens
38 ATP7B 540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 GALNT12 79695
Affinity Capture-MS Homo sapiens
40 TMTC3 160418
Affinity Capture-MS Homo sapiens
41 SREBF2 6721
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 NEK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 INTS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SFXN2  
Affinity Capture-MS Homo sapiens
45 B3GALNT2 148789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RDH11 51109
Affinity Capture-MS Homo sapiens
47 PLXNA3 55558
Affinity Capture-MS Homo sapiens
48 RNF130  
Affinity Capture-MS Homo sapiens
49 C1GALT1C1 29071
Affinity Capture-MS Homo sapiens
50 DDX11L8  
Affinity Capture-MS Homo sapiens
51 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LAPTM4B  
Two-hybrid Homo sapiens
53 GLOD4 51031
Affinity Capture-MS Homo sapiens
54 TMEM39B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GLMN 11146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MS4A4A  
Two-hybrid Homo sapiens
57 B3GNT3 10331
Affinity Capture-MS Homo sapiens
58 GALNT5 11227
Affinity Capture-MS Homo sapiens
59 DAD1 1603
Affinity Capture-MS Homo sapiens
60 ERBB4 2066
Reconstituted Complex Homo sapiens
61 EGFR 1956
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
62 MYO19  
Affinity Capture-MS Homo sapiens
63 SLC25A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 KIAA1467 57613
Affinity Capture-MS Homo sapiens
65 SLC35B2 347734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SLC38A10 124565
Affinity Capture-MS Homo sapiens
67 SEMA6B 10501
Affinity Capture-MS Homo sapiens
68 GALNT11 63917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 DSE 29940
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ABCB10 23456
Affinity Capture-MS Homo sapiens
71 NDUFA3  
Affinity Capture-MS Homo sapiens
72 LEMD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 SLC22A18 5002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 MBOAT7 79143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 SLC25A16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PLP1 5354
Two-hybrid Homo sapiens
77 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 LSR 51599
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 PGAP1 80055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 SPINT1 6692
Affinity Capture-MS Homo sapiens
82 DNAAF5 54919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 TUBB3 10381
Affinity Capture-MS Homo sapiens
84 SLC25A15  
Affinity Capture-MS Homo sapiens
85 PIGU 128869
Affinity Capture-MS Homo sapiens
86 SLC35F6 54978
Affinity Capture-MS Homo sapiens
87 SLC25A4 291
Affinity Capture-MS Homo sapiens
88 EXTL3 2137
Affinity Capture-MS Homo sapiens
89 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
91 SPTLC2 9517
Affinity Capture-MS Homo sapiens
92 MGST3 4259
Affinity Capture-MS Homo sapiens
93 CDC5L 988
Affinity Capture-MS Homo sapiens
94 HLA-C 3107
Affinity Capture-MS Homo sapiens
95 KIAA0922  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NRG1 is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Downregulation of ERBB2:ERBB3 signaling TAS Reactome
ERBB2 Activates PTK6 Signaling TAS Reactome
ERBB2 Regulates Cell Motility TAS Reactome
GRB2 events in ERBB2 signaling TAS Reactome
GRB7 events in ERBB2 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Long-term potentiation IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Nuclear signaling by ERBB4 IEA Reactome
PI3K events in ERBB2 signaling TAS Reactome
PI3K events in ERBB4 signaling TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Post NMDA receptor activation events IEA Reactome
RAF/MAP kinase cascade TAS Reactome
SHC1 events in ERBB2 signaling IEA Reactome
SHC1 events in ERBB2 signaling TAS Reactome
SHC1 events in ERBB4 signaling TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by ERBB4 IEA Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by PTK6 TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Transmission across Chemical Synapses IEA Reactome





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