Gene description for Hist1h2bb
Gene name histone cluster 1, H2bb
Gene symbol Hist1h2bb
Other names/aliases H2b-143
Species Mus musculus
 Database cross references - Hist1h2bb
ExoCarta ExoCarta_319178
Vesiclepedia VP_319178
Entrez Gene 319178
UniProt Q64475  
 Hist1h2bb identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Hist1h2bb
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Subcellular Localization
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Hist1h2bb in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hist1h2bb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rnf20  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Cbx1  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Cbx5  
Affinity Capture-MS Mus musculus
5 Fos  
Affinity Capture-Western Mus musculus
6 Fancd2  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
7 Jun  
Affinity Capture-Western Mus musculus
8 Cbx3 12417
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hist1h2bb is involved
PathwayEvidenceSource
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance IEA Reactome
Cleavage of the damaged purine IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
Deposition of new CENPA-containing nucleosomes at the centromere IEA Reactome
Depurination IEA Reactome
DNA Damage/Telomere Stress Induced Senescence IEA Reactome
DNA Double Strand Break Response IEA Reactome
DNA Double-Strand Break Repair IEA Reactome
DNA Repair IEA Reactome
E3 ubiquitin ligases ubiquitinate target proteins IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M DNA damage checkpoint IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HDACs deacetylate histones IEA Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) IEA Reactome
Homology Directed Repair IEA Reactome
Inhibition of DNA recombination at telomere IEA Reactome
M Phase IEA Reactome
Metabolism of proteins IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Nonhomologous End-Joining (NHEJ) IEA Reactome
Nucleosome assembly IEA Reactome
Post-translational protein modification IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Processing of DNA double-strand break ends IEA Reactome
Protein ubiquitination IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Signal Transduction IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Telomere Maintenance IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome





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