Gene description for Igf2bp2
Gene name insulin-like growth factor 2 mRNA binding protein 2
Gene symbol Igf2bp2
Other names/aliases C330012H03Rik
IMP-2
Imp2
Neilsen
Species Mus musculus
 Database cross references - Igf2bp2
ExoCarta ExoCarta_319765
Vesiclepedia VP_319765
Entrez Gene 319765
UniProt Q5SF07  
 Igf2bp2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Igf2bp2
Molecular Function
    RNA binding GO:0003723 IEA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    mRNA 3'-UTR binding GO:0003730 ISO
    mRNA 3'-UTR binding GO:0003730 ISS
    mRNA 5'-UTR binding GO:0048027 IDA
    mRNA 5'-UTR binding GO:0048027 ISO
    mRNA 5'-UTR binding GO:0048027 ISS
    translation regulator activity, nucleic acid binding GO:0090079 IMP
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
Biological Process
    regulation of translation GO:0006417 IEA
    nervous system development GO:0007399 IBA
    negative regulation of translation GO:0017148 IMP
    mRNA transport GO:0051028 IEA
    CRD-mediated mRNA stabilization GO:0070934 IBA
    CRD-mediated mRNA stabilization GO:0070934 ISO
    CRD-mediated mRNA stabilization GO:0070934 ISS
    energy homeostasis GO:0097009 IMP
    cold-induced thermogenesis GO:0106106 IMP
Subcellular Localization
    P-body GO:0000932 IEA
    P-body GO:0000932 ISO
    P-body GO:0000932 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytoskeleton GO:0005856 ISO
    cytoskeleton GO:0005856 ISS
    cytoplasmic stress granule GO:0010494 IEA
    cytoplasmic stress granule GO:0010494 ISO
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified Igf2bp2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Igf2bp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCBP2 5094
Two-hybrid Homo sapiens
2 PCBP3 54039
Two-hybrid Homo sapiens
3 Twist1  
Proximity Label-MS Mus musculus
4 Elf5  
Affinity Capture-MS Mus musculus
5 RBFOX2 23543
Two-hybrid Homo sapiens
6 Eed  
Affinity Capture-MS Mus musculus
7 Rbm14  
Two-hybrid Mus musculus
8 Nlrp3  
Affinity Capture-MS Mus musculus
9 PTBP1 5725
Two-hybrid Homo sapiens
10 Fancd2  
Affinity Capture-MS Mus musculus
11 Pcbp1 23983
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Igf2bp2 is involved
No pathways found





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