Gene description for TREML1
Gene name triggering receptor expressed on myeloid cells-like 1
Gene symbol TREML1
Other names/aliases GLTL1825
PRO3438
TLT-1
TLT1
dJ238O23.3
Species Homo sapiens
 Database cross references - TREML1
ExoCarta ExoCarta_340205
Vesiclepedia VP_340205
Entrez Gene 340205
HGNC 20434
MIM 609714
UniProt Q86YW5  
 TREML1 identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for TREML1
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IBA
    calcium-mediated signaling GO:0019722 IDA
    platelet activation GO:0030168 IBA
    platelet activation GO:0030168 IEP
    innate immune response GO:0045087 NAS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    cell surface GO:0009986 IEA
    membrane GO:0016020 NAS
    nuclear speck GO:0016607 IDA
    platelet alpha granule GO:0031091 IDA
    platelet alpha granule GO:0031091 IEA
 Experiment description of studies that identified TREML1 in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TREML1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS8 5652
Affinity Capture-MS Homo sapiens
2 EZR 7430
Affinity Capture-MS Homo sapiens
3 PTPN11 5781
Affinity Capture-Western Homo sapiens
4 TMBIM6 7009
Two-hybrid Homo sapiens
5 ATP1A3 478
Affinity Capture-MS Homo sapiens
6 PTPN6 5777
Affinity Capture-Western Homo sapiens
7 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



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