Gene description for AGBL3
Gene name ATP/GTP binding protein-like 3
Gene symbol AGBL3
Other names/aliases CCP3
Species Homo sapiens
 Database cross references - AGBL3
ExoCarta ExoCarta_340351
Vesiclepedia VP_340351
Entrez Gene 340351
HGNC 27981
UniProt Q8NEM8  
 AGBL3 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for AGBL3
Molecular Function
    metallocarboxypeptidase activity GO:0004181 IBA
    metallocarboxypeptidase activity GO:0004181 IDA
    zinc ion binding GO:0008270 IEA
    tubulin binding GO:0015631 IBA
Biological Process
    proteolysis GO:0006508 IEA
    protein side chain deglutamylation GO:0035610 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    centriole GO:0005814 IBA
    cytosol GO:0005829 IEA
    microtubule cytoskeleton GO:0015630 IBA
 Experiment description of studies that identified AGBL3 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AGBL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLIC3 9022
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 C17orf97  
Affinity Capture-MS Homo sapiens
4 ECT2 1894
Affinity Capture-MS Homo sapiens
5 KIF20A 10112
Affinity Capture-MS Homo sapiens
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