Gene description for INHBB
Gene name inhibin, beta B
Gene symbol INHBB
Other names/aliases -
Species Homo sapiens
 Database cross references - INHBB
ExoCarta ExoCarta_3625
Vesiclepedia VP_3625
Entrez Gene 3625
HGNC 6067
MIM 147390
UniProt P09529  
 INHBB identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for INHBB
Molecular Function
    cytokine activity GO:0005125 IBA
    cytokine activity GO:0005125 TAS
    hormone activity GO:0005179 TAS
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    protein homodimerization activity GO:0042803 IPI
    host cell surface receptor binding GO:0046789 TAS
Biological Process
    ovarian follicle development GO:0001541 NAS
    defense response GO:0006952 TAS
    spermatogenesis GO:0007283 IEA
    cellular response to starvation GO:0009267 ISS
    response to wounding GO:0009611 IEP
    response to insecticide GO:0017085 IEA
    pituitary gland development GO:0021983 IEA
    cell differentiation GO:0030154 NAS
    negative regulation of hepatocyte growth factor production GO:0032686 IDA
    cellular response to insulin stimulus GO:0032869 ISS
    activin receptor signaling pathway GO:0032924 IDA
    response to gonadotropin GO:0034698 IEA
    cellular response to leptin stimulus GO:0044320 IEA
    adhesion of symbiont to host cell GO:0044650 IEA
    fat cell differentiation GO:0045444 ISS
    negative regulation of insulin secretion GO:0046676 ISS
    positive regulation of follicle-stimulating hormone secretion GO:0046881 IPI
    negative regulation of follicle-stimulating hormone secretion GO:0046882 IPI
    oocyte development GO:0048599 IEA
    positive regulation of ovulation GO:0060279 ISS
    cellular response to calcium ion GO:0071277 IEA
    cellular response to cAMP GO:0071320 IEA
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to cholesterol GO:0071397 IEA
    seminiferous tubule development GO:0072520 IEA
    cellular response to thyroid hormone stimulus GO:0097067 IEA
    apoptotic signaling pathway GO:0097190 IEA
    cellular response to Thyroglobulin triiodothyronine GO:1904017 IEA
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    cell periphery GO:0071944 IEA
 Experiment description of studies that identified INHBB in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for INHBB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGSF1  
Co-localization Homo sapiens
2 PKN1 5585
Affinity Capture-MS Homo sapiens
3 ACVR1C  
Co-localization Homo sapiens
4 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
5 TDGF1  
Reconstituted Complex Homo sapiens
6 ACVR2A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 Cfc1  
Reconstituted Complex Mus musculus
8 BMPR2 659
Reconstituted Complex Homo sapiens
9 ACVR2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
10 FNTA 2339
Two-hybrid Homo sapiens
11 ACVR1B 91
Affinity Capture-Western Homo sapiens
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