Gene description for Rab4
Gene name CG4921 gene product from transcript CG4921-RA
Gene symbol Rab4
Other names/aliases CG 4921
CG4921
DRAB4
DmRab4
DmelCG4921
Q7KY04
RAB4c
rab4
Species Drosophila melanogaster
 Database cross references - Rab4
ExoCarta ExoCarta_36992
Vesiclepedia VP_36992
Entrez Gene 36992
 Rab4 identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Rab4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    follicle cell of egg chamber-cell adhesion GO:0007299 IMP
Subcellular Localization
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 HDA
    neuronal cell body GO:0043025 IDA
    synapse GO:0045202 HDA
    synapse GO:0045202 IDA
    recycling endosome GO:0055037 IDA
 Experiment description of studies that identified Rab4 in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sc2  
Affinity Capture-MS Drosophila melanogaster
2 CG14767  
Affinity Capture-MS Drosophila melanogaster
3 Syb  
Affinity Capture-MS Drosophila melanogaster
4 CG3164 33171
Affinity Capture-MS Drosophila melanogaster
5 atl  
Affinity Capture-MS Drosophila melanogaster
6 Scamp  
Affinity Capture-MS Drosophila melanogaster
7 Esp  
Affinity Capture-MS Drosophila melanogaster
8 CG42394  
Affinity Capture-MS Drosophila melanogaster
9 CG5447  
Affinity Capture-MS Drosophila melanogaster
10 RhoGAP68F  
Two-hybrid Drosophila melanogaster
11 CG7668  
Affinity Capture-MS Drosophila melanogaster
12 MRP  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Rab4 is involved
No pathways found





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