Gene description for KRT84
Gene name keratin 84, type II
Gene symbol KRT84
Other names/aliases HB4
KRTHB4
Species Homo sapiens
 Database cross references - KRT84
ExoCarta ExoCarta_3890
Vesiclepedia VP_3890
Entrez Gene 3890
HGNC 6461
MIM 602766
UniProt Q9NSB2  
 KRT84 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for KRT84
Molecular Function
    structural constituent of cytoskeleton GO:0005200 NAS
    structural constituent of skin epidermis GO:0030280 IBA
Biological Process
    hair follicle development GO:0001942 NAS
    keratinization GO:0031424 IBA
    nail development GO:0035878 NAS
    intermediate filament organization GO:0045109 IBA
    regulation of keratinocyte differentiation GO:0045616 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT84 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for KRT84
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT72 140807
Cross-Linking-MS (XL-MS) Homo sapiens
2 KRT76 51350
Cross-Linking-MS (XL-MS) Homo sapiens
3 KRT77 374454
Cross-Linking-MS (XL-MS) Homo sapiens
4 STARD8  
Affinity Capture-MS Homo sapiens
5 KRT73 319101
Cross-Linking-MS (XL-MS) Homo sapiens
6 GAN 8139
Affinity Capture-MS Homo sapiens
7 KRT3 3850
Cross-Linking-MS (XL-MS) Homo sapiens
8 KRT6B 3854
Cross-Linking-MS (XL-MS) Homo sapiens
9 USP37  
Affinity Capture-MS Homo sapiens
10 KRT6A 3853
Cross-Linking-MS (XL-MS) Homo sapiens
11 KRT17 3872
Cross-Linking-MS (XL-MS) Homo sapiens
12 KRT10 3858
Cross-Linking-MS (XL-MS) Homo sapiens
13 KRT5 3852
Cross-Linking-MS (XL-MS) Homo sapiens
14 CUL3 8452
Affinity Capture-MS Homo sapiens
15 DES 1674
Cross-Linking-MS (XL-MS) Homo sapiens
16 NHLRC2 374354
Affinity Capture-MS Homo sapiens
17 PRPH 5630
Cross-Linking-MS (XL-MS) Homo sapiens
18 KRT71 112802
Cross-Linking-MS (XL-MS) Homo sapiens
19 CBL 867
Affinity Capture-MS Homo sapiens
20 USP36  
Affinity Capture-MS Homo sapiens
21 KRT15 3866
Cross-Linking-MS (XL-MS) Homo sapiens
22 KRT6C 286887
Cross-Linking-MS (XL-MS) Homo sapiens
23 KRT20 54474
Cross-Linking-MS (XL-MS) Homo sapiens
24 KRT74 121391
Cross-Linking-MS (XL-MS) Homo sapiens
25 KRT75 9119
Cross-Linking-MS (XL-MS) Homo sapiens
26 METTL3  
Affinity Capture-MS Homo sapiens
27 KRT14 3861
Cross-Linking-MS (XL-MS) Homo sapiens
28 KRT2 3849
Cross-Linking-MS (XL-MS) Homo sapiens
29 VIM 7431
Cross-Linking-MS (XL-MS) Homo sapiens
30 KRT19 3880
Cross-Linking-MS (XL-MS) Homo sapiens
31 DDX39B 7919
Affinity Capture-MS Homo sapiens
32 KRT79 338785
Cross-Linking-MS (XL-MS) Homo sapiens
33 KRT7 3855
Cross-Linking-MS (XL-MS) Homo sapiens
34 KRT16 3868
Cross-Linking-MS (XL-MS) Homo sapiens
35 CYLD  
Affinity Capture-MS Homo sapiens
36 CCDC8  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KRT84 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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