Gene description for C5orf46
Gene name chromosome 5 open reading frame 46
Gene symbol C5orf46
Other names/aliases SSSP1
Species Homo sapiens
 Database cross references - C5orf46
ExoCarta ExoCarta_389336
Vesiclepedia VP_389336
Entrez Gene 389336
HGNC 33768
UniProt Q6UWT4  
 C5orf46 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for C5orf46
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified C5orf46 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for C5orf46
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC30A2  
Two-hybrid Homo sapiens
2 TMBIM6 7009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SGTA 6449
Two-hybrid Homo sapiens
4 ACACA 31
Positive Genetic Homo sapiens
5 PEX12  
Two-hybrid Homo sapiens
6 PPCS 79717
Affinity Capture-MS Homo sapiens
7 SGTB  
Two-hybrid Homo sapiens
8 C16orf58 64755
Two-hybrid Homo sapiens
9 TMEM80  
Two-hybrid Homo sapiens
10 EBP  
Two-hybrid Homo sapiens
11 LHFPL5  
Two-hybrid Homo sapiens
12 FAM210B  
Two-hybrid Homo sapiens
13 TIMMDC1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C5orf46 is involved
No pathways found





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