Gene description for ZBTB34
Gene name zinc finger and BTB domain containing 34
Gene symbol ZBTB34
Other names/aliases ZNF918
Species Homo sapiens
 Database cross references - ZBTB34
ExoCarta ExoCarta_403341
Vesiclepedia VP_403341
Entrez Gene 403341
HGNC 31446
MIM 611692
UniProt Q8NCN2  
 ZBTB34 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZBTB34
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleoplasm GO:0005654 IBA
 Experiment description of studies that identified ZBTB34 in sEVs
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZBTB34
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB37  
Affinity Capture-MS Homo sapiens
2 BTRC 8945
Affinity Capture-MS Homo sapiens
3 FBXW11  
Affinity Capture-MS Homo sapiens
4 FOXP3  
Affinity Capture-MS Homo sapiens
5 TDRKH  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
6 TH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNF579  
Affinity Capture-MS Homo sapiens
8 ZBTB24  
Affinity Capture-MS Homo sapiens
9 FOXJ2  
Affinity Capture-MS Homo sapiens
10 FOXN3 1112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ZBTB26  
Two-hybrid Homo sapiens
12 FOXC2  
Affinity Capture-MS Homo sapiens
13 MAFG  
Affinity Capture-MS Homo sapiens
14 PIAS4  
Two-hybrid Homo sapiens
15 ABTB2 25841
Affinity Capture-MS Homo sapiens
16 ZNF496  
Affinity Capture-MS Homo sapiens
17 ZBTB9  
Affinity Capture-MS Homo sapiens
18 KLHL24  
Affinity Capture-MS Homo sapiens
19 NACC2  
Affinity Capture-MS Homo sapiens
20 CHEK1  
Affinity Capture-MS Homo sapiens
21 L3MBTL1  
Affinity Capture-MS Homo sapiens
22 KLHL22 84861
Affinity Capture-MS Homo sapiens
23 FBLN5 10516
Affinity Capture-MS Homo sapiens
24 FOXE1  
Affinity Capture-MS Homo sapiens
25 KLHL21 9903
Affinity Capture-MS Homo sapiens
26 CEBPA  
Proximity Label-MS Homo sapiens
27 BACH2 60468
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB34 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here