Gene description for Mapk3
Gene name	mitogen activated protein kinase 3
Gene symbol	Mapk3
Other names/aliases	ERK1 ERT2 Erk-1 Esrk1 MAPK1 MNK1 Prkm3 p44 p44erk1 p44mapk
Species	Rattus norvegicus
Database cross references - Mapk3
ExoCarta	ExoCarta_50689
Vesiclepedia	VP_50689
Entrez Gene	50689
UniProt	P21708
Mapk3 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Mapk3

Molecular Function     phosphotyrosine residue binding GO:0001784 ISO     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IC     protein serine/threonine kinase activity GO:0004674 ISO     JUN kinase activity GO:0004705 IEA     MAP kinase activity GO:0004707 IDA     MAP kinase activity GO:0004707 IEA     MAP kinase activity GO:0004707 IMP     MAP kinase activity GO:0004707 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     phosphatase binding GO:0019902 ISO     identical protein binding GO:0042802 ISO     scaffold protein binding GO:0097110 IPI     protein serine kinase activity GO:0106310 IEA     DNA-binding transcription factor binding GO:0140297 ISO Biological Process     MAPK cascade GO:0000165 IEA     MAPK cascade GO:0000165 IMP     MAPK cascade GO:0000165 ISO     DNA-templated transcription GO:0006351 ISO     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 ISO     protein phosphorylation GO:0006468 ISO     protein phosphorylation GO:0006468 TAS     apoptotic process GO:0006915 IEA     DNA damage response GO:0006974 ISO     cell surface receptor signaling pathway GO:0007166 IBA     JNK cascade GO:0007254 IEA     insulin receptor signaling pathway GO:0008286 ISO     response to toxic substance GO:0009636 IDA     animal organ morphogenesis GO:0009887 ISO     positive regulation of macrophage chemotaxis GO:0010759 ISO     neural crest cell development GO:0014032 ISO     Schwann cell development GO:0014044 ISO     phosphorylation GO:0016310 ISO     peptidyl-serine phosphorylation GO:0018105 IMP     sensory perception of pain GO:0019233 ISO     arachidonate metabolic process GO:0019369 IEP     regulation of ossification GO:0030278 ISO     BMP signaling pathway GO:0030509 ISO     regulation of cellular pH GO:0030641 ISO     thyroid gland development GO:0030878 ISO     positive regulation of cyclase activity GO:0031281 ISO     lipopolysaccharide-mediated signaling pathway GO:0031663 ISO     positive regulation of telomere maintenance GO:0032206 ISO     response to lipopolysaccharide GO:0032496 ISO     regulation of stress-activated MAPK cascade GO:0032872 IEA     regulation of stress-activated MAPK cascade GO:0032872 TAS     cellular response to amino acid starvation GO:0034198 ISO     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 IDA     intracellular signal transduction GO:0035556 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 ISO     ERBB2-ERBB3 signaling pathway GO:0038133 ISO     outer ear morphogenesis GO:0042473 ISO     myelination GO:0042552 ISO     signal transduction in response to DNA damage GO:0042770 ISO     response to exogenous dsRNA GO:0043330 ISO     positive regulation of translation GO:0045727 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     decidualization GO:0046697 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 ISO     thymus development GO:0048538 ISO     modulation of chemical synaptic transmission GO:0050804 ISO     regulation of DNA-binding transcription factor activity GO:0051090 ISO     cartilage development GO:0051216 ISO     stress-activated MAPK cascade GO:0051403 ISO     regulation of cytoskeleton organization GO:0051493 IEA     regulation of cytoskeleton organization GO:0051493 TAS     Bergmann glial cell differentiation GO:0060020 ISO     face development GO:0060324 ISO     lung morphogenesis GO:0060425 ISO     trachea formation GO:0060440 ISO     cardiac neural crest cell development involved in heart development GO:0061308 ISO     protein-containing complex assembly GO:0065003 IMP     ERK1 and ERK2 cascade GO:0070371 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     interleukin-1-mediated signaling pathway GO:0070498 ISO     response to epidermal growth factor GO:0070849 ISO     response to epidermal growth factor GO:0070849 ISS     cellular response to mechanical stimulus GO:0071260 ISO     cellular response to tumor necrosis factor GO:0071356 ISO     caveolin-mediated endocytosis GO:0072584 IEA     caveolin-mediated endocytosis GO:0072584 TAS     regulation of Golgi inheritance GO:0090170 IEA     regulation of Golgi inheritance GO:0090170 TAS     cellular response to toxic substance GO:0097237 IDA     xenophagy GO:0098792 ISO     positive regulation of macrophage proliferation GO:0120041 ISO     negative regulation of TORC1 signaling GO:1904262 ISO     positive regulation of xenophagy GO:1904417 ISO     regulation of early endosome to late endosome transport GO:2000641 IEA     regulation of early endosome to late endosome transport GO:2000641 TAS Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleus GO:0005634 TAS     nuclear envelope GO:0005635 ISO     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 TAS     early endosome GO:0005769 IEA     early endosome GO:0005769 TAS     late endosome GO:0005770 IEA     late endosome GO:0005770 TAS     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 TAS     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     cytoskeleton GO:0005856 TAS     plasma membrane GO:0005886 IDA     caveola GO:0005901 IDA     caveola GO:0005901 IEA     caveola GO:0005901 TAS     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 TAS     pseudopodium GO:0031143 ISO     protein-containing complex GO:0032991 IDA     glutamatergic synapse GO:0098978 ISO