Gene description for ATL1
Gene name atlastin GTPase 1
Gene symbol ATL1
Other names/aliases AD-FSP
FSP1
GBP3
HSN1D
SPG3
SPG3A
atlastin1
Species Homo sapiens
 Database cross references - ATL1
ExoCarta ExoCarta_51062
Vesiclepedia VP_51062
Entrez Gene 51062
HGNC 11231
MIM 606439
UniProt Q8WXF7  
 ATL1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ATL1
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISS
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    endoplasmic reticulum organization GO:0007029 IBA
    endoplasmic reticulum organization GO:0007029 IDA
    axonogenesis GO:0007409 ISS
    protein homooligomerization GO:0051260 IBA
    protein homooligomerization GO:0051260 IDA
    endoplasmic reticulum tubular network membrane organization GO:1990809 IMP
Subcellular Localization
    Golgi cis cisterna GO:0000137 ISS
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 ISS
    Golgi apparatus GO:0005794 ISS
    membrane GO:0016020 IDA
    axon GO:0030424 IEA
    endoplasmic reticulum tubular network GO:0071782 ISS
    endoplasmic reticulum tubular network membrane GO:0098826 IDA
 Experiment description of studies that identified ATL1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-Western Homo sapiens
2 REEP5 7905
Proximity Label-MS Homo sapiens
3 TM4SF5  
Affinity Capture-MS Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 RPN2 6185
Proximity Label-MS Homo sapiens
7 ATL3 25923
Affinity Capture-MS Homo sapiens
8 METTL7A 25840
Proximity Label-MS Homo sapiens
9 LRRC59 55379
Proximity Label-MS Homo sapiens
10 KIAA1715 80856
Proximity Label-MS Homo sapiens
11 AMFR 267
Affinity Capture-Western Homo sapiens
12 BCAP31 10134
Proximity Label-MS Homo sapiens
13 HSD3B7 80270
Proximity Label-MS Homo sapiens
14 STIM1 6786
Proximity Label-MS Homo sapiens
15 EMD 2010
Proximity Label-MS Homo sapiens
16 PTPN1 5770
Proximity Label-MS Homo sapiens
17 SYVN1 84447
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
18 STX4 6810
Proximity Label-MS Homo sapiens
19 RTN4 57142
Affinity Capture-MS Homo sapiens
20 PJA1  
Affinity Capture-Western Homo sapiens
21 B3GAT1  
Proximity Label-MS Homo sapiens
22 SEC62 7095
Proximity Label-MS Homo sapiens
23 ATP2A1 487
Proximity Label-MS Homo sapiens
24 NTRK1 4914
Affinity Capture-MS Homo sapiens
25 RAB7A 7879
Proximity Label-MS Homo sapiens
26 RAB9A 9367
Proximity Label-MS Homo sapiens
27 COPB2 9276
Affinity Capture-MS Homo sapiens
28 STX7 8417
Proximity Label-MS Homo sapiens
29 RPN1 6184
Proximity Label-MS Homo sapiens
30 COPA 1314
Affinity Capture-MS Homo sapiens
31 SSR1 6745
Proximity Label-MS Homo sapiens
32 CKAP4 10970
Proximity Label-MS Homo sapiens
33 RNF185  
Affinity Capture-Western Homo sapiens
34 ESYT1 23344
Affinity Capture-MS Homo sapiens
35 POLR1D 51082
Affinity Capture-MS Homo sapiens
36 SEC61B 10952
Proximity Label-MS Homo sapiens
37 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATL1 is involved
No pathways found





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