Gene description for PLCE1
Gene name	phospholipase C, epsilon 1
Gene symbol	PLCE1
Other names/aliases	NPHS3 PLCE PPLC
Species	Homo sapiens
Database cross references - PLCE1
ExoCarta	ExoCarta_51196
Vesiclepedia	VP_51196
Entrez Gene	51196
HGNC	17175
MIM	608414
UniProt	Q9P212
PLCE1 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells	20124223

Gene ontology annotations for PLCE1

Molecular Function     phosphatidylinositol phospholipase C activity GO:0004435 IBA     phosphatidylinositol phospholipase C activity GO:0004435 IDA     phospholipase C activity GO:0004629 IDA     guanyl-nucleotide exchange factor activity GO:0005085 TAS     protein binding GO:0005515 IPI     enzyme binding GO:0019899 IPI     small GTPase binding GO:0031267 IDA     metal ion binding GO:0046872 IEA Biological Process     diacylglycerol biosynthetic process GO:0006651 IMP     diacylglycerol biosynthetic process GO:0006651 TAS     epidermal growth factor receptor signaling pathway GO:0007173 IMP     epidermal growth factor receptor signaling pathway GO:0007173 NAS     G protein-coupled receptor signaling pathway GO:0007186 IBA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IDA     Ras protein signal transduction GO:0007265 IBA     Ras protein signal transduction GO:0007265 IDA     positive regulation of lamellipodium assembly GO:0010592 IMP     lipid catabolic process GO:0016042 IEA     calcium-mediated signaling GO:0019722 NAS     glomerulus development GO:0032835 IMP     intracellular signal transduction GO:0035556 IDA     phosphatidylinositol metabolic process GO:0046488 IBA     phosphatidylinositol-mediated signaling GO:0048015 IBA     release of sequestered calcium ion into cytosol GO:0051209 IBA Subcellular Localization     Golgi membrane GO:0000139 IEA     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     lamellipodium GO:0030027 IDA