Gene description for HEATR5B
Gene name HEAT repeat containing 5B
Gene symbol HEATR5B
Other names/aliases -
Species Homo sapiens
 Database cross references - HEATR5B
ExoCarta ExoCarta_54497
Vesiclepedia VP_54497
Entrez Gene 54497
HGNC 29273
UniProt Q9P2D3  
 HEATR5B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HEATR5B
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IBA
    protein localization GO:0008104 IBA
    protein transport GO:0015031 IEA
    retrograde transport, endosome to Golgi GO:0042147 IBA
Subcellular Localization
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
    nuclear speck GO:0016607 IDA
    clathrin-coated vesicle GO:0030136 IEA
    endocytic vesicle GO:0030139 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified HEATR5B in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HEATR5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX27 81609
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 AP2B1 163
Proximity Label-MS Homo sapiens
4 EFNA4  
Affinity Capture-MS Homo sapiens
5 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GPR17 2840
Affinity Capture-MS Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 XPO1 7514
Affinity Capture-MS Homo sapiens
9 PTPN3  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 SQSTM1 8878
Proximity Label-MS Homo sapiens
11 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NPTN 27020
Affinity Capture-MS Homo sapiens
13 ATG9A 79065
Proximity Label-MS Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 AP1S2 8905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 CLTA 1211
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 AP1B1 162
Affinity Capture-MS Homo sapiens
19 AP1S3  
Affinity Capture-MS Homo sapiens
20 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ANKRD22  
Affinity Capture-MS Homo sapiens
22 RAB43 339122
Affinity Capture-MS Homo sapiens
23 RPA3 6119
Proximity Label-MS Homo sapiens
24 NTRK1 4914
Affinity Capture-MS Homo sapiens
25 RAB7A 7879
Proximity Label-MS Homo sapiens
26 IFI16 3428
Affinity Capture-MS Homo sapiens
27 AP1M2 10053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SERBP1 26135
Affinity Capture-MS Homo sapiens
29 HSPD1 3329
Cross-Linking-MS (XL-MS) Homo sapiens
30 CCDC8  
Affinity Capture-MS Homo sapiens
31 RAB11A 8766
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HEATR5B is involved
No pathways found





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