Gene description for KLHDC4
Gene name kelch domain containing 4
Gene symbol KLHDC4
Other names/aliases -
Species Homo sapiens
 Database cross references - KLHDC4
ExoCarta ExoCarta_54758
Vesiclepedia VP_54758
Entrez Gene 54758
HGNC 25272
UniProt Q8TBB5  
 KLHDC4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KLHDC4
Molecular Function
    protein binding GO:0005515 IPI
 Experiment description of studies that identified KLHDC4 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KLHDC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NXF1 10482
Affinity Capture-RNA Homo sapiens
3 CROT 54677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SUV39H1  
Two-hybrid Homo sapiens
5 PARK2  
Affinity Capture-MS Homo sapiens
6 TERF1 7013
Two-hybrid Homo sapiens
7 KDM1A 23028
Two-hybrid Homo sapiens
8 CEP76  
Two-hybrid Homo sapiens
9 MOV10 4343
Affinity Capture-RNA Homo sapiens
10 HSP90AB1 3326
Co-fractionation Homo sapiens
11 PMAIP1  
Affinity Capture-MS Homo sapiens
12 SUV39H2 79723
Two-hybrid Homo sapiens
13 TRIM55  
Two-hybrid Homo sapiens
14 CES2 8824
Affinity Capture-MS Homo sapiens
15 AHR 196
Affinity Capture-MS Homo sapiens
16 SHMT2 6472
Affinity Capture-RNA Homo sapiens
17 TRIM63  
Two-hybrid Homo sapiens
18 RPS19 6223
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which KLHDC4 is involved
No pathways found





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