Gene description for HYDIN
Gene name HYDIN, axonemal central pair apparatus protein
Gene symbol HYDIN
Other names/aliases CILD5
HYDIN1
HYDIN2
PPP1R31
Species Homo sapiens
 Database cross references - HYDIN
ExoCarta ExoCarta_54768
Vesiclepedia VP_54768
Entrez Gene 54768
HGNC 19368
MIM 610812
UniProt Q4G0P3  
 HYDIN identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for HYDIN
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell development GO:0002064 IEA
    cilium movement GO:0003341 IBA
    ventricular system development GO:0021591 IEA
    trachea development GO:0060438 IEA
    axonemal central apparatus assembly GO:1904158 IBA
Subcellular Localization
    axoneme GO:0005930 IBA
    axonemal central apparatus GO:1990716 ISS
    axonemal central pair projection GO:1990718 IEA
 Experiment description of studies that identified HYDIN in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HYDIN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EXOC4 60412
Cross-Linking-MS (XL-MS) Homo sapiens
2 HNRNPU 3192
Cross-Linking-MS (XL-MS) Homo sapiens
3 TBCA 6902
Cross-Linking-MS (XL-MS) Homo sapiens
4 CUL3 8452
Affinity Capture-MS Homo sapiens
5 PEF1 553115
Two-hybrid Homo sapiens
6 UBC 7316
Reconstituted Complex Homo sapiens
7 NUDC 10726
Cross-Linking-MS (XL-MS) Homo sapiens
8 ERRFI1 54206
Two-hybrid Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 DYNC1H1 1778
Cross-Linking-MS (XL-MS) Homo sapiens
11 FOXP1 27086
Protein-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which HYDIN is involved
No pathways found





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