Gene description for WDR70
Gene name WD repeat domain 70
Gene symbol WDR70
Other names/aliases -
Species Homo sapiens
 Database cross references - WDR70
ExoCarta ExoCarta_55100
Vesiclepedia VP_55100
Entrez Gene 55100
HGNC 25495
UniProt Q9NW82  
 WDR70 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for WDR70
Molecular Function
    enzyme binding GO:0019899 IPI
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    site of double-strand break GO:0035861 IBA
 Experiment description of studies that identified WDR70 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WDR70
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 PLCD4  
Affinity Capture-MS Homo sapiens
4 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLX4  
Affinity Capture-MS Homo sapiens
6 Klc3  
Affinity Capture-MS Mus musculus
7 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PDCL3 79031
Affinity Capture-MS Homo sapiens
9 AMOTL1 154810
Affinity Capture-MS Homo sapiens
10 RBPJ 3516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MRPS2 51116
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 CCT2 10576
Affinity Capture-MS Homo sapiens
14 RIT1 6016
Negative Genetic Homo sapiens
15 E2F4  
Affinity Capture-MS Homo sapiens
16 PRPF38A 84950
Affinity Capture-MS Homo sapiens
17 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
18 ACTC1 70
Proximity Label-MS Homo sapiens
19 NOP56 10528
Proximity Label-MS Homo sapiens
20 Ccdc12  
Affinity Capture-MS Mus musculus
21 NUP50 10762
Proximity Label-MS Homo sapiens
22 EGFR 1956
Negative Genetic Homo sapiens
23 PARK2  
Affinity Capture-MS Homo sapiens
24 TSSC4  
Co-fractionation Homo sapiens
25 MRPS28  
Affinity Capture-MS Homo sapiens
26 SUPT5H 6829
Co-fractionation Homo sapiens
27 SIRT1  
Affinity Capture-MS Homo sapiens
28 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CCT5 22948
Affinity Capture-MS Homo sapiens
30 GTF2E1 2960
Co-fractionation Homo sapiens
31 APEX1 328
Proximity Label-MS Homo sapiens
32 CBX3 11335
Proximity Label-MS Homo sapiens
33 DDX23 9416
Proximity Label-MS Homo sapiens
34 CALU 813
Co-fractionation Homo sapiens
35 WDR48 57599
Affinity Capture-MS Homo sapiens
36 RPA3 6119
Proximity Label-MS Homo sapiens
37 RASA2 5922
Affinity Capture-MS Homo sapiens
38 DYRK1A 1859
Affinity Capture-MS Homo sapiens
39 ZC3H18  
Co-fractionation Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 RPS6 6194
Proximity Label-MS Homo sapiens
42 PARP1 142
Proximity Label-MS Homo sapiens
43 FBXL6  
Proximity Label-MS Homo sapiens
44 RPA4  
Proximity Label-MS Homo sapiens
45 UBTF 7343
Co-fractionation Homo sapiens
46 KRAS 3845
Negative Genetic Homo sapiens
47 MRPS24 64951
Affinity Capture-MS Homo sapiens
48 SYT2  
Affinity Capture-MS Homo sapiens
49 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
50 YAP1 10413
Affinity Capture-MS Homo sapiens
51 Tecpr2  
Affinity Capture-MS Mus musculus
52 TCEANC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CHORDC1 26973
Affinity Capture-MS Homo sapiens
54 PLCD3 113026
Affinity Capture-MS Homo sapiens
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