Gene description for NKRF
Gene name NFKB repressing factor
Gene symbol NKRF
Other names/aliases ITBA4
NRF
Species Homo sapiens
 Database cross references - NKRF
ExoCarta ExoCarta_55922
Vesiclepedia VP_55922
Entrez Gene 55922
HGNC 19374
MIM 300440
UniProt O15226  
 NKRF identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NKRF
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    ATPase activator activity GO:0001671 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of DNA-templated transcription GO:0045892 IBA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified NKRF in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NKRF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 GATA1  
Proximity Label-MS Homo sapiens
4 ZNF668  
Affinity Capture-MS Homo sapiens
5 RPSA 3921
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Affinity Capture-MS Homo sapiens
7 Eif4a2 13682
Two-hybrid Mus musculus
8 ZNF346  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
9 KPNA1 3836
Affinity Capture-MS Homo sapiens
10 RNF4 6047
Affinity Capture-MS Homo sapiens
11 RPL30 6156
Affinity Capture-MS Homo sapiens
12 TARDBP 23435
Affinity Capture-MS Homo sapiens
13 Nfyc 18046
Affinity Capture-MS Mus musculus
14 REL 5966
Reconstituted Complex Homo sapiens
15 RPL13A 23521
Affinity Capture-MS Homo sapiens
16 RPL37A 6168
Affinity Capture-MS Homo sapiens
17 NOP56 10528
Proximity Label-MS Homo sapiens
18 RPS19 6223
Affinity Capture-MS Homo sapiens
19 CHCHD1  
Proximity Label-MS Homo sapiens
20 RPL14 9045
Affinity Capture-MS Homo sapiens
21 XRN2 22803
Affinity Capture-MS Homo sapiens
22 VHL  
Affinity Capture-MS Homo sapiens
23 CAND1 55832
Affinity Capture-MS Homo sapiens
24 SOX2  
Affinity Capture-MS Homo sapiens
25 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DDX23 9416
Proximity Label-MS Homo sapiens
27 PARK2  
Affinity Capture-MS Homo sapiens
28 KIF23 9493
Affinity Capture-MS Homo sapiens
29 COPS5 10987
Affinity Capture-MS Homo sapiens
30 METAP2 10988
Affinity Capture-MS Homo sapiens
31 RPS10 6204
Affinity Capture-MS Homo sapiens
32 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 POLR1E  
Proximity Label-MS Homo sapiens
34 SRP19 6728
Affinity Capture-MS Homo sapiens
35 OBSL1 23363
Affinity Capture-MS Homo sapiens
36 GSPT1 2935
Affinity Capture-MS Homo sapiens
37 ADARB1 104
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
38 PRKRA 8575
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
39 SRP68 6730
Affinity Capture-MS Homo sapiens
40 MECP2 4204
Affinity Capture-MS Homo sapiens
41 CUL1 8454
Affinity Capture-MS Homo sapiens
42 ARIH2 10425
Affinity Capture-MS Homo sapiens
43 RBM42  
Affinity Capture-MS Homo sapiens
44 OASL 8638
Affinity Capture-MS Homo sapiens
45 RPL19 6143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RBM14 10432
Affinity Capture-MS Homo sapiens
47 CTCF  
Affinity Capture-MS Homo sapiens
48 KIF14 9928
Affinity Capture-MS Homo sapiens
49 LIN28A  
Affinity Capture-MS Homo sapiens
50 CPEB1  
Affinity Capture-MS Homo sapiens
51 E2F4  
Affinity Capture-MS Homo sapiens
52 UFL1 23376
Affinity Capture-MS Homo sapiens
53 KIFC1 3833
Two-hybrid Homo sapiens
54 SRP9 6726
Affinity Capture-MS Homo sapiens
55 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
56 DDX21 9188
Affinity Capture-MS Homo sapiens
57 THAP3  
Affinity Capture-MS Homo sapiens
58 RPL4 6124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TARBP2  
Two-hybrid Homo sapiens
60 ZBTB47  
Affinity Capture-MS Homo sapiens
61 SRSF3 6428
Affinity Capture-MS Homo sapiens
62 YBX2 51087
Affinity Capture-MS Homo sapiens
63 STAU1 6780
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
64 SRSF6 6431
Affinity Capture-MS Homo sapiens
65 PURG  
Affinity Capture-MS Homo sapiens
66 RPL5 6125
Affinity Capture-MS Homo sapiens
67 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
68 Srp72  
Affinity Capture-MS Mus musculus
69 FOXL2  
Affinity Capture-MS Homo sapiens
70 YAP1 10413
Affinity Capture-MS Homo sapiens
71 BARD1 580
Affinity Capture-MS Homo sapiens
72 DDX5 1655
Affinity Capture-MS Homo sapiens
73 NTRK1 4914
Affinity Capture-MS Homo sapiens
74 RPL31 6160
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
77 PARP1 142
Proximity Label-MS Homo sapiens
78 CBX6  
Affinity Capture-MS Homo sapiens
79 BCL6  
Affinity Capture-MS Homo sapiens
80 Rrbp1  
Affinity Capture-MS Mus musculus
81 HECTD1 25831
Affinity Capture-MS Homo sapiens
82 RPLP0 6175
Affinity Capture-MS Homo sapiens
83 LYAR 55646
Affinity Capture-MS Homo sapiens
84 MAGEB2 4113
Affinity Capture-MS Homo sapiens
85 KDF1  
Affinity Capture-MS Homo sapiens
86 WDR46  
Affinity Capture-MS Homo sapiens
87 CNBP 7555
Affinity Capture-MS Homo sapiens
88 ANLN 54443
Affinity Capture-MS Homo sapiens
89 FGFBP1 9982
Affinity Capture-MS Homo sapiens
90 C9orf72  
Affinity Capture-MS Homo sapiens
91 ZBTB2 57621
Affinity Capture-MS Homo sapiens
92 UBE2H 7328
Affinity Capture-MS Homo sapiens
93 ABT1 29777
Affinity Capture-MS Homo sapiens
94 RPL7A 6130
Affinity Capture-MS Homo sapiens
95 RPS2 6187
Affinity Capture-MS Homo sapiens
96 RC3H2  
Affinity Capture-MS Homo sapiens
97 RELA 5970
Reconstituted Complex Homo sapiens
98 SIRT7  
Affinity Capture-MS Homo sapiens
99 RPL35 11224
Affinity Capture-MS Homo sapiens
100 HMOX2 3163
Two-hybrid Homo sapiens
101 SRSF1 6426
Affinity Capture-MS Homo sapiens
102 NPM3 10360
Affinity Capture-MS Homo sapiens
103 USP36  
Affinity Capture-MS Homo sapiens
104 PHIP 55023
Affinity Capture-MS Homo sapiens
105 CUL3 8452
Affinity Capture-MS Homo sapiens
106 CIT 11113
Affinity Capture-MS Homo sapiens
107 SRSF5 6430
Affinity Capture-MS Homo sapiens
108 RPL3 6122
Affinity Capture-MS Homo sapiens
109 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
110 DHX30 22907
Affinity Capture-MS Homo sapiens
111 MYC  
Affinity Capture-MS Homo sapiens
112 RPL7 6129
Affinity Capture-MS Homo sapiens
113 ZC3H10  
Affinity Capture-MS Homo sapiens
114 NXF1 10482
Affinity Capture-RNA Homo sapiens
115 LOC100132735  
Protein-RNA Homo sapiens
116 JUN 3725
Affinity Capture-MS Homo sapiens
117 MYCN  
Affinity Capture-MS Homo sapiens
118 PRR3  
Affinity Capture-MS Homo sapiens
119 RBM4B  
Affinity Capture-MS Homo sapiens
120 PSPC1 55269
Affinity Capture-MS Homo sapiens
121 RPA3 6119
Proximity Label-MS Homo sapiens
122 NFKB1 4790
Reconstituted Complex Homo sapiens
123 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
124 DDRGK1 65992
Affinity Capture-MS Homo sapiens
125 BMI1  
Affinity Capture-MS Homo sapiens
126 FOXQ1  
Affinity Capture-MS Homo sapiens
127 Rpl35 66489
Affinity Capture-MS Mus musculus
128 RPL11 6135
Affinity Capture-MS Homo sapiens
129 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
130 PEX3 8504
Proximity Label-MS Homo sapiens
131 ZC3H3  
Affinity Capture-MS Homo sapiens
132 RPS16 6217
Affinity Capture-MS Homo sapiens
133 DHX9 1660
Affinity Capture-MS Homo sapiens
134 RPL13 6137
Affinity Capture-MS Homo sapiens
135 DHX15 1665
Two-hybrid Homo sapiens
136 SURF6  
Affinity Capture-MS Homo sapiens
137 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
138 RNF151  
Affinity Capture-MS Homo sapiens
139 SIRT6  
Affinity Capture-MS Homo sapiens
140 RBM19 9904
Affinity Capture-MS Homo sapiens
141 ILF3 3609
Affinity Capture-MS Homo sapiens
142 TP53 7157
Affinity Capture-MS Homo sapiens
143 MNDA 4332
Affinity Capture-MS Homo sapiens
144 APEX1 328
Proximity Label-MS Homo sapiens
145 NFKB2 4791
Reconstituted Complex Homo sapiens
146 MEN1 4221
Affinity Capture-MS Homo sapiens
147 DGCR8  
Affinity Capture-MS Homo sapiens
148 SMURF1 57154
Affinity Capture-MS Homo sapiens
149 H2AFB3  
Affinity Capture-MS Homo sapiens
150 MKI67  
Affinity Capture-MS Homo sapiens
151 NIFK 84365
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 DRG1 4733
Affinity Capture-MS Homo sapiens
153 DHX40  
Proximity Label-MS Homo sapiens
154 DHX58 79132
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
155 KRR1 11103
Affinity Capture-MS Homo sapiens
156 NEIL1  
Affinity Capture-MS Homo sapiens
157 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
158 RPS24 6229
Proximity Label-MS Homo sapiens
159 MOV10 4343
Affinity Capture-RNA Homo sapiens
160 IL17B 27190
Affinity Capture-MS Homo sapiens
161 SRSF7 6432
Affinity Capture-MS Homo sapiens
162 RBM8A 9939
Affinity Capture-MS Homo sapiens
163 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 RPL8 6132
Affinity Capture-MS Homo sapiens
165 GRSF1 2926
Proximity Label-MS Homo sapiens
166 RPL23A 6147
Affinity Capture-MS Homo sapiens
167 KRAS 3845
Affinity Capture-MS Homo sapiens
168 HNRNPU 3192
Affinity Capture-MS Homo sapiens
169 GNB2L1 10399
Affinity Capture-MS Homo sapiens
170 RC3H1 149041
Affinity Capture-MS Homo sapiens
171 PRMT1 3276
Affinity Capture-MS Homo sapiens
172 ZNF467  
Affinity Capture-MS Homo sapiens
173 KLF5  
Proximity Label-MS Homo sapiens
174 Stau2  
Two-hybrid Mus musculus
175 EP300 2033
Affinity Capture-MS Homo sapiens
176 NHLH1  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NKRF is involved
No pathways found





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