Gene description for Stx8
Gene name syntaxin 8
Gene symbol Stx8
Other names/aliases 0610007H08Rik
1110002H11Rik
4930571E13Rik
CARB
Species Mus musculus
 Database cross references - Stx8
ExoCarta ExoCarta_55943
Vesiclepedia VP_55943
Entrez Gene 55943
UniProt O88983  
 Stx8 identified in sEVs derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Stx8
Molecular Function
    SNARE binding GO:0000149 IBA
    SNARE binding GO:0000149 ISO
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    chloride channel inhibitor activity GO:0019869 IEA
    chloride channel inhibitor activity GO:0019869 ISO
    syntaxin binding GO:0019905 IEA
    syntaxin binding GO:0019905 ISO
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    intracellular protein transport GO:0006886 IBA
    vesicle fusion GO:0006906 IBA
    vesicle fusion GO:0006906 ISO
    endosome to lysosome transport GO:0008333 ISO
    vesicle-mediated transport GO:0016192 ISO
    early endosome to late endosome transport GO:0045022 IEA
    early endosome to late endosome transport GO:0045022 ISO
    vesicle docking GO:0048278 IBA
    cellular response to type II interferon GO:0071346 IDA
    regulation of protein localization to plasma membrane GO:1903076 IEA
    regulation of protein localization to plasma membrane GO:1903076 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    endosome GO:0005768 ISO
    early endosome GO:0005769 IEA
    early endosome GO:0005769 ISO
    late endosome GO:0005770 IDA
    late endosome GO:0005770 ISO
    trans-Golgi network GO:0005802 IEA
    trans-Golgi network GO:0005802 ISO
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 IEA
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 ISO
    late endosome membrane GO:0031902 ISO
    vesicle GO:0031982 ISO
    phagocytic vesicle GO:0045335 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome GO:0055037 IEA
    recycling endosome GO:0055037 ISO
 Experiment description of studies that identified Stx8 in sEVs
1
Experiment ID 14
MISEV standards
✔
EM
Biophysical techniques
✔
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
✔
DNM
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Stx8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR1 90
Affinity Capture-Luminescence Homo sapiens
2 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml
 Pathways in which Stx8 is involved
No pathways found





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