Gene description for Dstn
Gene name destrin
Gene symbol Dstn
Other names/aliases 2610043P17Rik
ADF
AU042046
Dsn
corn1
sid23p
Species Mus musculus
 Database cross references - Dstn
ExoCarta ExoCarta_56431
Vesiclepedia VP_56431
Entrez Gene 56431
UniProt Q9R0P5  
 Dstn identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dstn
Molecular Function
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
    actin filament binding GO:0051015 ISO
    actin filament binding GO:0051015 ISS
Biological Process
    cytokinesis GO:0000910 IMP
    actin filament depolymerization GO:0030042 IDA
    actin filament depolymerization GO:0030042 ISO
    actin filament fragmentation GO:0030043 IBA
    actin filament fragmentation GO:0030043 IDA
    positive regulation of actin filament depolymerization GO:0030836 IMP
    cell motility GO:0048870 IMP
    actin filament severing GO:0051014 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    actin cytoskeleton GO:0015629 IBA
    cortical actin cytoskeleton GO:0030864 IDA
    presynapse GO:0098793 IDA
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Dstn in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dstn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Tnik  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
5 VASP 7408
Affinity Capture-MS Homo sapiens
6 Cyfip1 20430
Affinity Capture-MS Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
9 Mapt  
Affinity Capture-MS Mus musculus
10 MTNR1A  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
11 Actg1 11465
Co-fractionation Mus musculus
12 Fancd2  
Affinity Capture-MS Mus musculus
13 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Dstn is involved
No pathways found





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