Gene description for Arpc1a
Gene name actin related protein 2/3 complex, subunit 1A
Gene symbol Arpc1a
Other names/aliases 0610010H08Rik
1110030K07Rik
41kDa
AA407347
Sid32
Sid329
Species Mus musculus
 Database cross references - Arpc1a
ExoCarta ExoCarta_56443
Vesiclepedia VP_56443
Entrez Gene 56443
UniProt Q9R0Q6  
 Arpc1a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Arpc1a
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IBA
Biological Process
    Arp2/3 complex-mediated actin nucleation GO:0034314 IBA
    Arp2/3 complex-mediated actin nucleation GO:0034314 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IEA
    Arp2/3 protein complex GO:0005885 IBA
    Arp2/3 protein complex GO:0005885 ISS
    Arp2/3 protein complex GO:0005885 TAS
    site of double-strand break GO:0035861 ISS
    muscle cell projection membrane GO:0036195 IDA
    synapse GO:0045202 IDA
    synapse GO:0045202 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Arpc1a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Arpc1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Calu  
Co-fractionation Mus musculus
2 Tprkb  
Co-fractionation Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Mtr  
Co-fractionation Mus musculus
5 Zbtb7b  
Affinity Capture-MS Mus musculus
6 Agap2  
Affinity Capture-MS Mus musculus
7 Arpc5l 74192
Co-fractionation Mus musculus
8 PLEKHO1 51177
Two-hybrid Homo sapiens
9 Thg1l  
Co-fractionation Mus musculus
View the network image/svg+xml



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