Gene description for TENM2
Gene name teneurin transmembrane protein 2
Gene symbol TENM2
Other names/aliases ODZ2
TEN-M2
TNM2
Species Homo sapiens
 Database cross references - TENM2
ExoCarta ExoCarta_57451
Vesiclepedia VP_57451
Entrez Gene 57451
HGNC 29943
MIM 610119
 TENM2 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for TENM2
Molecular Function
    signaling receptor binding GO:0005102 IDA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IBA
    protein homodimerization activity GO:0042803 ISS
    protein heterodimerization activity GO:0046982 IBA
    protein heterodimerization activity GO:0046982 ISS
    cell adhesion molecule binding GO:0050839 IBA
    cell adhesion molecule binding GO:0050839 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    signal transduction GO:0007165 IEA
    neuron development GO:0048666 IBA
    positive regulation of filopodium assembly GO:0051491 ISS
    cell-cell adhesion GO:0098609 ISS
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 EXP
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    cell-cell junction GO:0005911 IDA
    PML body GO:0016605 ISS
    cell junction GO:0030054 ISS
    filopodium GO:0030175 ISS
    dendrite GO:0030425 ISS
    growth cone GO:0030426 ISS
    neuron projection GO:0043005 IBA
    neuron projection GO:0043005 ISS
    dendritic spine GO:0043197 ISS
    synapse GO:0045202 ISS
    postsynaptic membrane GO:0045211 ISS
 Experiment description of studies that identified TENM2 in sEVs
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TENM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which TENM2 is involved
No pathways found





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