Gene description for LRRN1
Gene name leucine rich repeat neuronal 1
Gene symbol LRRN1
Other names/aliases FIGLER3
NLRR-1
Species Homo sapiens
 Database cross references - LRRN1
ExoCarta ExoCarta_57633
Vesiclepedia VP_57633
Entrez Gene 57633
HGNC 20980
UniProt Q6UXK5  
 LRRN1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for LRRN1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of synapse assembly GO:0051965 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified LRRN1 in sEVs
1
Experiment ID 834
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LRRN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRD 5789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NGEF  
Affinity Capture-MS Homo sapiens
3 ST7  
Affinity Capture-MS Homo sapiens
4 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRN1 is involved
No pathways found





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