Gene description for LHPP
Gene name phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Gene symbol LHPP
Other names/aliases HDHD2B
Species Homo sapiens
 Database cross references - LHPP
ExoCarta ExoCarta_64077
Vesiclepedia VP_64077
Entrez Gene 64077
HGNC 30042
UniProt Q9H008  
 LHPP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LHPP
Molecular Function
    inorganic diphosphate phosphatase activity GO:0004427 IBA
    inorganic diphosphate phosphatase activity GO:0004427 IDA
    protein binding GO:0005515 IPI
    phosphatase activity GO:0016791 IBA
    protein homodimerization activity GO:0042803 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    phosphate-containing compound metabolic process GO:0006796 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified LHPP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LHPP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GDPGP1  
Co-fractionation Homo sapiens
2 C12orf10 60314
Affinity Capture-MS Homo sapiens
3 MYH7 4625
Affinity Capture-MS Homo sapiens
4 RPIA 22934
Affinity Capture-MS Homo sapiens
5 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
6 SPSB4  
Affinity Capture-MS Homo sapiens
7 ZSCAN23  
Two-hybrid Homo sapiens
8 SERTAD1  
Affinity Capture-MS Homo sapiens
9 OTUB1 55611
Affinity Capture-MS Homo sapiens
10 HDHD2 84064
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CLIC2 1193
Affinity Capture-MS Homo sapiens
12 SLBP  
Affinity Capture-MS Homo sapiens
13 MYH8 4626
Affinity Capture-MS Homo sapiens
14 CREG1 8804
Affinity Capture-MS Homo sapiens
15 MYH1  
Affinity Capture-MS Homo sapiens
16 OVOL2  
Affinity Capture-MS Homo sapiens
17 HMX2  
Affinity Capture-MS Homo sapiens
18 NOTCH2NL 388677
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LHPP is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Pyrophosphate hydrolysis TAS Reactome





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