Gene description for Fgf23
Gene name fibroblast growth factor 23
Gene symbol Fgf23
Other names/aliases -
Species Mus musculus
 Database cross references - Fgf23
ExoCarta ExoCarta_64654
Vesiclepedia VP_64654
Entrez Gene 64654
UniProt Q9EPC2  
 Fgf23 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fgf23
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IPI
    type 1 fibroblast growth factor receptor binding GO:0005105 IBA
    type 1 fibroblast growth factor receptor binding GO:0005105 IPI
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    MAPK cascade GO:0000165 IDA
    positive regulation of cell population proliferation GO:0008284 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 IPI
    regulation of phosphate transport GO:0010966 IEA
    regulation of phosphate transport GO:0010966 ISO
    positive regulation of vitamin D 24-hydroxylase activity GO:0010980 ISO
    neurogenesis GO:0022008 IBA
    cell differentiation GO:0030154 IEA
    regulation of cell migration GO:0030334 IBA
    regulation of bone mineralization GO:0030500 IMP
    negative regulation of bone mineralization GO:0030502 IEA
    negative regulation of bone mineralization GO:0030502 ISO
    intracellular phosphate ion homeostasis GO:0030643 IMP
    response to magnesium ion GO:0032026 IEA
    vitamin D catabolic process GO:0042369 IEA
    vitamin D catabolic process GO:0042369 ISO
    positive regulation of MAPK cascade GO:0043410 IBA
    cellular response to leptin stimulus GO:0044320 IEA
    negative regulation of osteoblast differentiation GO:0045668 IEA
    negative regulation of osteoblast differentiation GO:0045668 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    negative regulation of hormone secretion GO:0046888 ISO
    negative regulation of hormone secretion GO:0046888 ISS
    phosphate ion homeostasis GO:0055062 ISO
    calcium ion homeostasis GO:0055074 IDA
    ERK1 and ERK2 cascade GO:0070371 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    cellular response to vitamin D GO:0071305 IEA
    cellular response to interleukin-6 GO:0071354 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IGI
    response to sodium phosphate GO:1904383 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Fgf23 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Fgf23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fgfr4  
Affinity Capture-Western Mus musculus
2 Fgfr1 14182
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
3 Phex  
Co-fractionation Mus musculus
4 Fgfr3  
Affinity Capture-Western Mus musculus
5 Kl  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Fgf23 is involved
PathwayEvidenceSource
Downstream signaling of activated FGFR1 IEA Reactome
Downstream signaling of activated FGFR2 IEA Reactome
Downstream signaling of activated FGFR3 IEA Reactome
Downstream signaling of activated FGFR4 IEA Reactome
FGFR1 ligand binding and activation IEA Reactome
FGFR1c and Klotho ligand binding and activation IEA Reactome
FGFR1c ligand binding and activation IEA Reactome
FGFR2 ligand binding and activation IEA Reactome
FGFR2c ligand binding and activation IEA Reactome
FGFR3 ligand binding and activation IEA Reactome
FGFR3c ligand binding and activation IEA Reactome
FGFR4 ligand binding and activation IEA Reactome
FGFRL1 modulation of FGFR1 signaling IEA Reactome
FRS-mediated FGFR1 signaling IEA Reactome
FRS-mediated FGFR2 signaling IEA Reactome
FRS-mediated FGFR3 signaling IEA Reactome
FRS-mediated FGFR4 signaling IEA Reactome
IGF1R signaling cascade IEA Reactome
Insulin receptor signalling cascade IEA Reactome
Intracellular signaling by second messengers IEA Reactome
IRS-mediated signalling IEA Reactome
IRS-related events triggered by IGF1R IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Metabolism of proteins IEA Reactome
Negative regulation of FGFR1 signaling IEA Reactome
Negative regulation of FGFR2 signaling IEA Reactome
Negative regulation of FGFR3 signaling IEA Reactome
Negative regulation of FGFR4 signaling IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
Phospholipase C-mediated cascade: FGFR1 IEA Reactome
Phospholipase C-mediated cascade; FGFR2 IEA Reactome
Phospholipase C-mediated cascade; FGFR3 IEA Reactome
Phospholipase C-mediated cascade; FGFR4 IEA Reactome
PI-3K cascade:FGFR1 IEA Reactome
PI-3K cascade:FGFR2 IEA Reactome
PI-3K cascade:FGFR3 IEA Reactome
PI-3K cascade:FGFR4 IEA Reactome
PI3K Cascade IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Post-translational protein modification IEA Reactome
Post-translational protein phosphorylation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IEA Reactome
SHC-mediated cascade:FGFR1 IEA Reactome
SHC-mediated cascade:FGFR2 IEA Reactome
SHC-mediated cascade:FGFR3 IEA Reactome
SHC-mediated cascade:FGFR4 IEA Reactome
Signal Transduction IEA Reactome
Signaling by FGFR IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Signaling by Insulin receptor IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IEA Reactome





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