Gene description for PLEKHG2
Gene name pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Gene symbol PLEKHG2
Other names/aliases ARHGEF42
CLG
Species Homo sapiens
 Database cross references - PLEKHG2
ExoCarta ExoCarta_64857
Vesiclepedia VP_64857
Entrez Gene 64857
HGNC 29515
MIM 611893
UniProt Q9H7P9  
 PLEKHG2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PLEKHG2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
Biological Process
    regulation of actin filament polymerization GO:0030833 IBA
    regulation of actin filament polymerization GO:0030833 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PLEKHG2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PLEKHG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 CDK1 983
Affinity Capture-MS Homo sapiens
3 MCRS1  
Affinity Capture-MS Homo sapiens
4 FHL1 2273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 GNG2 54331
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 CCNA2 890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DCK 1633
Affinity Capture-MS Homo sapiens
8 SKP2  
Affinity Capture-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 ACTN3 89
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 GNB1 2782
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 CKS1B  
Affinity Capture-MS Homo sapiens
13 XRN1 54464
Two-hybrid Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 CDC42 998
Reconstituted Complex Homo sapiens
16 CDK2 1017
Affinity Capture-MS Homo sapiens
17 TCTEX1D2  
Affinity Capture-MS Homo sapiens
18 GNAS 2778
Affinity Capture-Western Homo sapiens
19 DYNLRB1 83658
Proximity Label-MS Homo sapiens
20 FLNC 2318
Affinity Capture-MS Homo sapiens
21 CKS2  
Affinity Capture-MS Homo sapiens
22 RAC1 5879
Reconstituted Complex Homo sapiens
23 RHOA 387
Reconstituted Complex Homo sapiens
24 LPP 4026
Affinity Capture-MS Homo sapiens
25 FHL2 2274
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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