Gene description for Psmd5
Gene name proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Gene symbol Psmd5
Other names/aliases 1500032A03Rik
AW475925
S5b
W91691
mKIAA0072
Species Mus musculus
 Database cross references - Psmd5
ExoCarta ExoCarta_66998
Vesiclepedia VP_66998
Entrez Gene 66998
UniProt Q8BJY1  
 Psmd5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Psmd5
Biological Process
    proteasome regulatory particle assembly GO:0070682 IEA
    proteasome regulatory particle assembly GO:0070682 ISO
Subcellular Localization
    proteasome regulatory particle, base subcomplex GO:0008540 IEA
    proteasome regulatory particle, base subcomplex GO:0008540 ISO
    proteasome accessory complex GO:0022624 IDA
 Experiment description of studies that identified Psmd5 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Psmd5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmb7 19177
Co-fractionation Mus musculus
2 Psmc6 67089
Co-fractionation Mus musculus
3 Ubc  
Reconstituted Complex Mus musculus
4 Psme2 19188
Co-fractionation Mus musculus
5 Pnp 18950
Co-fractionation Mus musculus
6 Gmps 229363
Co-fractionation Mus musculus
7 Psmd2 21762
Co-fractionation Mus musculus
8 Psmc3 19182
Co-fractionation Mus musculus
9 Psma2 19166
Co-fractionation Mus musculus
10 Psmb6 19175
Co-fractionation Mus musculus
11 Psmc2 19181
Co-fractionation Mus musculus
12 Psmd4  
Co-fractionation Mus musculus
13 Psmd13 23997
Co-fractionation Mus musculus
14 Babam1  
Co-fractionation Mus musculus
15 Psmb1 19170
Co-fractionation Mus musculus
16 Vcp 269523
Co-fractionation Mus musculus
17 Psmb8 16913
Co-fractionation Mus musculus
18 Psmd9  
Co-fractionation Mus musculus
19 Psmc1 19179
Co-fractionation Mus musculus
20 Psmd1 70247
Co-fractionation Mus musculus
21 Cops2 12848
Co-fractionation Mus musculus
22 Psmd3 22123
Co-fractionation Mus musculus
23 Psme1 19186
Co-fractionation Mus musculus
24 Eed  
Affinity Capture-MS Mus musculus
25 Fancd2  
Affinity Capture-MS Mus musculus
26 Psmd11 69077
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Psmd5 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
Proteasome assembly IEA Reactome





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