Gene description for BTN1A1
Gene name butyrophilin, subfamily 1, member A1
Gene symbol BTN1A1
Other names/aliases BT
BTN
BTN1
Species Homo sapiens
 Database cross references - BTN1A1
ExoCarta ExoCarta_696
Vesiclepedia VP_696
Entrez Gene 696
HGNC 1135
MIM 601610
UniProt Q13410  
 BTN1A1 identified in sEVs derived from the following tissue/cell type
Breast milk 17641064    
Breast milk 17641064    
 Gene ontology annotations for BTN1A1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 TAS
Biological Process
    regulation of cytokine production GO:0001817 IBA
    T cell receptor signaling pathway GO:0050852 IBA
Subcellular Localization
    extracellular space GO:0005615 HDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
 Experiment description of studies that identified BTN1A1 in sEVs
1
Experiment ID 46
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
HSC70|CD63|MHCII|CD81|CD86
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 48
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
HSC70|CD63|CD86|MHCII
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for BTN1A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEOX2  
Two-hybrid Homo sapiens
2 PRC1 9055
Affinity Capture-MS Homo sapiens
3 TRIM11  
Affinity Capture-MS Homo sapiens
4 MOSPD2 158747
Two-hybrid Homo sapiens
5 DCX  
Affinity Capture-MS Homo sapiens
6 ATG4A  
Affinity Capture-MS Homo sapiens
7 CUL3 8452
Affinity Capture-MS Homo sapiens
8 NME5  
Affinity Capture-MS Homo sapiens
9 METTL14  
Affinity Capture-MS Homo sapiens
10 NTRK1 4914
Affinity Capture-MS Homo sapiens
11 TRIM68 55128
Affinity Capture-MS Homo sapiens
12 PLK1 5347
Affinity Capture-MS Homo sapiens
13 NEIL3  
Protein-RNA Homo sapiens
14 METTL3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BTN1A1 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Butyrophilin (BTN) family interactions TAS Reactome
Immune System TAS Reactome





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