Gene description for TGM4
Gene name transglutaminase 4
Gene symbol TGM4
Other names/aliases TGP
hTGP
Species Homo sapiens
 Database cross references - TGM4
ExoCarta ExoCarta_7047
Vesiclepedia VP_7047
Entrez Gene 7047
HGNC 11780
MIM 600585
UniProt P49221  
 TGM4 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for TGM4
Molecular Function
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IBA
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 NAS
    metal ion binding GO:0046872 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    collagen-containing extracellular matrix GO:0062023 IBA
    collagen-containing extracellular matrix GO:0062023 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TGM4 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TGM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RDH11 51109
Affinity Capture-MS Homo sapiens
2 TBC1D14 57533
Affinity Capture-MS Homo sapiens
3 DDHD2 23259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZNF418  
Affinity Capture-MS Homo sapiens
5 LRCH2  
Affinity Capture-MS Homo sapiens
6 GAB2 9846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DHH  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TGM4 is involved
No pathways found





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