Gene description for C8B
Gene name complement component 8, beta polypeptide
Gene symbol C8B
Other names/aliases C82
Species Homo sapiens
 Database cross references - C8B
ExoCarta ExoCarta_732
Vesiclepedia VP_732
Entrez Gene 732
HGNC 1353
MIM 120960
UniProt P07358  
 C8B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for C8B
Molecular Function
    protein-containing complex binding GO:0044877 IEA
Biological Process
    immune response GO:0006955 TAS
    complement activation GO:0006956 IBA
    complement activation, alternative pathway GO:0006957 IEA
    complement activation, classical pathway GO:0006958 IEA
    killing of cells of another organism GO:0031640 IEA
    positive regulation of immune response GO:0050778 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    membrane attack complex GO:0005579 IBA
    membrane attack complex GO:0005579 IDA
    membrane attack complex GO:0005579 IPI
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 NAS
    membrane GO:0016020 TAS
    extracellular exosome GO:0070062 HDA
    extracellular vesicle GO:1903561 HDA
 Experiment description of studies that identified C8B in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for C8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDM1B  
Affinity Capture-MS Homo sapiens
2 C5 727
Reconstituted Complex Homo sapiens
3 DPY19L3  
Affinity Capture-MS Homo sapiens
4 C8A 731
Cross-Linking-MS (XL-MS) Homo sapiens
5 HHIPL1 84439
Affinity Capture-MS Homo sapiens
6 CLU 1191
Reconstituted Complex Homo sapiens
7 PAPSS2 9060
Affinity Capture-MS Homo sapiens
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