Gene description for ZNF205
Gene name zinc finger protein 205
Gene symbol ZNF205
Other names/aliases RhitH
ZNF210
Zfp13
Species Homo sapiens
 Database cross references - ZNF205
ExoCarta ExoCarta_7755
Vesiclepedia VP_7755
Entrez Gene 7755
HGNC 12996
MIM 603436
UniProt O95201  
 ZNF205 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZNF205
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of DNA-templated transcription GO:0006355 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of hydrogen peroxide biosynthetic process GO:0010729 IMP
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified ZNF205 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZNF205
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNS2 23371
Two-hybrid Homo sapiens
2 UBQLN4 56893
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 HDAC6 10013
Two-hybrid Homo sapiens
4 UBQLN2 29978
Two-hybrid Homo sapiens
5 APEX1 328
Affinity Capture-RNA Homo sapiens
6 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
7 CDC37 11140
Two-hybrid Homo sapiens
8 ILK 3611
Two-hybrid Homo sapiens
9 MAPK6  
Two-hybrid Homo sapiens
10 CCDC85B  
Two-hybrid Homo sapiens
11 GOLGA6L9  
Two-hybrid Homo sapiens
12 MDFI  
Two-hybrid Homo sapiens
13 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
14 TRAF2 7186
Two-hybrid Homo sapiens
15 CALCOCO2  
Two-hybrid Homo sapiens
16 TSGA10  
Two-hybrid Homo sapiens
17 MEST 4232
Two-hybrid Homo sapiens
18 WT1  
Two-hybrid Homo sapiens
19 C8orf33 65265
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF205 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





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