Gene description for PCBD2
Gene name pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Gene symbol PCBD2
Other names/aliases DCOH2
DCOHM
PHS2
Species Homo sapiens
 Database cross references - PCBD2
ExoCarta ExoCarta_84105
Vesiclepedia VP_84105
Entrez Gene 84105
HGNC 24474
MIM 609836
UniProt Q9H0N5  
 PCBD2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCBD2
Molecular Function
    phenylalanine 4-monooxygenase activity GO:0004505 IEA
    protein binding GO:0005515 IPI
    4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124 IBA
    identical protein binding GO:0042802 IEA
Biological Process
    tetrahydrobiopterin biosynthetic process GO:0006729 IEA
    tyrosine biosynthetic process, by oxidation of phenylalanine GO:0019293 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 HTP
 Experiment description of studies that identified PCBD2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCBD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 CERS3  
Two-hybrid Homo sapiens
3 SSX5  
Two-hybrid Homo sapiens
4 TAL2  
Two-hybrid Homo sapiens
5 BRF1  
Two-hybrid Homo sapiens
6 BCAS2 10286
Two-hybrid Homo sapiens
7 AATF  
Two-hybrid Homo sapiens
8 MED4 29079
Two-hybrid Homo sapiens
9 MAGEA11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 CENPK  
Two-hybrid Homo sapiens
11 KLC3  
Two-hybrid Homo sapiens
12 HNF1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SSX3  
Two-hybrid Homo sapiens
14 MED7  
Two-hybrid Homo sapiens
15 ZZZ3  
Two-hybrid Homo sapiens
16 GUCD1  
Two-hybrid Homo sapiens
17 PHF14 9678
Two-hybrid Homo sapiens
18 MAGEA6  
Two-hybrid Homo sapiens
19 KCNIP3  
Two-hybrid Homo sapiens
20 XBP1  
Two-hybrid Homo sapiens
21 MED30  
Two-hybrid Homo sapiens
22 HES4  
Two-hybrid Homo sapiens
23 RUNX1T1  
Two-hybrid Homo sapiens
24 MED21  
Two-hybrid Homo sapiens
25 IRF2BP1 26145
Two-hybrid Homo sapiens
26 PBXIP1 57326
Two-hybrid Homo sapiens
27 ASCC2 84164
Two-hybrid Homo sapiens
28 CHAF1A  
Two-hybrid Homo sapiens
29 MRFAP1  
Two-hybrid Homo sapiens
30 GTF2E1 2960
Two-hybrid Homo sapiens
31 PCBD1 5092
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
32 METAP2 10988
Affinity Capture-MS Homo sapiens
33 C1D  
Two-hybrid Homo sapiens
34 HNF1B  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SNW1 22938
Two-hybrid Homo sapiens
36 PML 5371
Two-hybrid Homo sapiens
37 TGIF2LY  
Two-hybrid Homo sapiens
38 DBT 1629
Affinity Capture-MS Homo sapiens
39 STAT3 6774
Two-hybrid Homo sapiens
40 ILF3 3609
Affinity Capture-RNA Homo sapiens
41 CDC5L 988
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PCBD2 is involved
No pathways found





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