Experiment description of studies that identified C9orf64 in sEVs

1 Experiment ID 207 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DKO-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

2 Experiment ID 208 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name Dks-8 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 209 MISEV standards ✘ Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DLD-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

4 Experiment ID 217 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|CD81|CD9|CD63 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23844026     Organism Homo sapiens Experiment description Characterization of human thymic exosomes. Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O." Journal name PLoS One Publication year 2013 Sample Thymus Sample name Normal-Thymus Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for C9orf64

Protein Interactor ExoCarta ID Identification method PubMed Species 1 PRKD2 25865 Affinity Capture-MS Homo sapiens 2 PPIAL4G   Affinity Capture-MS Homo sapiens 3 NIF3L1 60491 Affinity Capture-MS Homo sapiens 4 PRNP 5621 Affinity Capture-MS Homo sapiens 5 SLC16A2   Affinity Capture-MS Homo sapiens 6 PKM 5315 Co-fractionation Homo sapiens 7 UBXN7 26043 Affinity Capture-MS Homo sapiens 8 FAM163B   Affinity Capture-MS Homo sapiens 9 NMRAL1 57407 Co-fractionation Homo sapiens 10 ELAVL1 1994 Affinity Capture-RNA Homo sapiens 11 LOC100132735   Protein-RNA Homo sapiens 12 DPYD 1806 Co-fractionation Homo sapiens 13 EMX2   Affinity Capture-MS Homo sapiens 14 DUSP28   Affinity Capture-MS Homo sapiens 15 XKR4   Affinity Capture-MS Homo sapiens 16 NTRK1 4914 Affinity Capture-MS Homo sapiens 17 ITPA 3704 Co-fractionation Homo sapiens 18 FH 2271 Co-fractionation Homo sapiens 19 CARKD 55739 Co-fractionation Homo sapiens 20 MEOX2   Two-hybrid Homo sapiens 21 POLL   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 22 DUSP21   Affinity Capture-MS Homo sapiens 23 NTSR1   Affinity Capture-MS Homo sapiens 24 NEDD8 4738 Co-fractionation Homo sapiens View the network

Pathways in which C9orf64 is involved

No pathways found