Gene description for BTBD10
Gene name BTB (POZ) domain containing 10
Gene symbol BTBD10
Other names/aliases GMRP-1
GMRP1
Species Homo sapiens
 Database cross references - BTBD10
ExoCarta ExoCarta_84280
Vesiclepedia VP_84280
Entrez Gene 84280
HGNC 21445
MIM 615933
UniProt Q9BSF8  
 BTBD10 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BTBD10
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IBA
    type B pancreatic cell proliferation GO:0044342 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified BTBD10 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BTBD10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP1CA 5499
Two-hybrid Homo sapiens
2 PPP1CC 5501
Two-hybrid Homo sapiens
3 CDC37 11140
Two-hybrid Homo sapiens
4 HECTD1 25831
Affinity Capture-MS Homo sapiens
5 MAPK3 5595
Two-hybrid Homo sapiens
6 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
7 APEX1 328
Affinity Capture-RNA Homo sapiens
8 Cul3  
Affinity Capture-MS Mus musculus
9 COPS7A 50813
Affinity Capture-MS Homo sapiens
10 ARRDC5  
Affinity Capture-MS Homo sapiens
11 DLG5 9231
Two-hybrid Homo sapiens
12 BUB3 9184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DUSP16  
Affinity Capture-MS Homo sapiens
14 Taf15  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which BTBD10 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here